The article is dedicated to the physiological mechanisms of change of urine formation, clinically significant and associated with the function of the Henle loop, water and sodium reabsorption. The molecular mechanisms of regulation violations of urine formation in the clinic of internal diseases, depending on the structures of the brain substance of the kidneys, are analyzed

Кeywords: autacoids, neuropeptides, osmolality, water reabsorbtion, poliuria, kidney