Русский
Efficacy and safety of antiviral therapy with glecaprevir+ pibrentasvir for patients with chronic hepatitis c and chronic kidney disease
DOI: https://dx.doi.org/10.18565/nephrology.2018.4.55-61
E.A. Strebkova, O.V. Agafonova, E.S. Kindalova, V.P. Varkentin, A.M. Kalyshenko
1 FSBEI HE "Samara State Medical University" of the Ministry of Health of the Russian Federation; Russia, Samara; 2 SBHCI "Samara Regional Clinical Center for the Prevention and Control of AIDS"; Samara, Russia
Material and Methods. 13 patients with chronic hepatitis C and chronic kidney disease were examined, including
8 men and 5 women. The average age was 48±3.14 years. Antiviral therapy (AVT) was carried out for 8 and 12 weeks. General clinical and biochemical blood tests were performed; for patients with HIV co-infection, the HIV RNA viral load and the CD4+lymphocyte levels were monitored.
Results. 12 patients completed the full course of AVT. One of them had an AVT course for 10 weeks due to the development of non-AVT-associated side effects in the form of infection of vascular access for program hemodialysis, accompanied by an increase in body temperature to 40°C. Nevertheless, all 13 patients had a sustained virological response (100%). Ten patients had normalization of alanine aminotransferase indices on the background or after termination of the AVT.
Conclusion. The AVT scheme "glecaprevir+pibrentasvir" demonstrated a 100% effectiveness for patients with viral hepatitis C and chronic kidney disease stage III–V, including patients on program hemodialysis, and also showed a satisfactory safety profile.
About the Autors
Strebkova E.A. – PhD in Medical Sciences, Associate Professor at the Department of Infectious Diseases with a Course of Epidemiology FSBEI HE SSMU of the Ministry of Health
of the Russian Federation; Russia, Samara.
Agafonova O.V. – PhD in Medical Sciences, Deputy Chief Physician of the SBHCI "Samara Regional Clinical Center for the Prevention and Control of AIDS"; Russia, Samara.
Kindalova E.S. – PhD in Medical Sciences, Infectious Diseases Physician of the First Qualification Category at the Clinic of Infectious Diseases FSBEI HE SSMU of the Ministry
of Health of the Russian Federation; Russia, Samara.
Varkentin V.P. – Infectious Diseases Physician at the Clinic of Infectious Diseases FSBEI HE SSMU of the Ministry of Health of the Russian Federation; Russia, Samara.
Kalyshenko A.M. – Head of the Department for the Treatment of Patients with HIV SBHCI "Samara Regional Clinical Center for the Prevention and Control of AIDS"; Russia, Samara.
