Kidney damage in Covid-19: clinical-pathogenetic aspects and management of patients with chronic kidney disease


DOI: https://dx.doi.org/10.18565/nephrology.2021.1.63-67

Sh. S.Abdullaev, R.Sh. Igamberdiyeva, O.N. Sharapov

1) Tashkent Paediatric Medical Institute, Tashkent, Uzbekistan; 2) Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Tashkent, Uzbekistan
In this review, we discuss the chronic immunological changes observed in patients with chronic kidney disease (CKD), the risk of COVID-19 infection, and the clinical implications and specific COVID-19 therapy in CKD patients. Actually, the risk of severe COVID-19 in CKD patients is 3 times higher than in patients without CKD; CKD in the intensive care unit is 12 times more common than in non-hospitalized patients with COVID-19, and this ratio is higher than in patients with diabetes mellitus or cardiovascular diseases; and mortality rate from COVID-19 is 15–25% among hemodialysis patients, even if pneumonia does not develop.
Keywords: chronic kidney disease, COVID-19, SARS-CoV-2, cytokine storm, renin-angiotensin-aldosterone system, hemodialysis, cardiovascular diseases, antiviral drugs, vitamin D, nephroprotection
Read entire article

About the Autors

Sherzod S. Abdullaev – Dr. Sci. (Med.), Associate Professor at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute, Tashkent; e-mail: dr.sherzod@rambler.ru
ORCID: 0000-0003-0640-5976
Ranokhon Sh. Igamberdiyeva – Teaching Assistant at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute; Tashkent; e-mail: rano1982@yandex.ru
ORCID: 0000-0002-7314-0309
Olimkhon N. Sharapov – Doctoral Student at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute; Nephrologist at the Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation; Tashkent; e-mail: olimkhon@gmail.com ORCID: 0000-0003-2452-416X

Back to Content

Бионика Медиа