Clinical evaluation of uropathogen selection in vivo


DOI: https://dx.doi.org/10.18565/nephrology.2023.1.65-69

Berdichevsky V.B., Berdichevsky B.A., Sapozhenkova E.V., Pavlova I.V., Gonyaev A.A., Boldyrev A.L., Korabelnikov M.A., Petrov D.I., Spirina D.S.

1) Tyumen State Medical University, Tyumen, Russia; 2) Regional Clinical Hospital № 2, Tyumen, Russia; 3) Medical and Sanitary Unit “Neftyanik”, Tyumen, Russia; 4) Clinical Hospital “Mother and Child”, Tyumen, Russia; 5) Radiology Center, MCMC "Medical City", Tyumen, Russia
Background. Unraveling the mechanisms of bacterial gene expression in vivo that induce pathogenic properties when they are in their host will help to identify new applications in the development of antimicrobials.
Objective. Evaluation of the influence of glucose metabolism in the urinary tract (UT) on the implementation of bacteriuria manifestations.
Material and methods. A retrospective laboratory and PET/CT molecular-cellular analysis of glucose metabolism in the bladder in conjunction with the features of the clinical manifestations of bacteriuria was carried out.
Results. New data on biosynthetic and metabolic processes that induce the ability of bacteria to various manifestations of their presence in the human MF have been obtained
Conclusion. The selection of pathogenic properties in typical representatives of the urinary tract microbiota, which determine the clinical form of bacteriuria, may be associated with the features of glucose metabolism in the organs of the urinary system, which needs special study and clarification.

About the Autors


Berdichevsky Vadim Borisovich – Doctor of Medical Sciences, Professor of the Department of Oncology with a course of urology, Tyumen State Medical University of the Ministry of Health of Russia. Address: 625023 Tyumen, st. Odessa, 54; e-mail: urotgmu@mail.ru.
Berdichevsky Boris Arkadyevich – Doctor of Medical Sciences, Professor, Professor of the Department of Oncology with a Course in Urology, Tyumen State Medical University of the Ministry of Health of Russia. Address: 625023 Tyumen, st. Odessa, 54; e-mail: urotgmu@mail.ru.
Sapozhenkova Ekaterina Valerievna – Candidate of Medical Sciences, Associate Professor of the Department of Normal Physiology Tyumen State Medical University of the Ministry of Health of Russia. Address: 625023 Tyumen, st. Odessa, 54; e-mail: ekaterina_chibulaeva@mail.ru.
Pavlova Irina Valerievna – Urologist of the Department of Urology of JSC “Medical and Sanitary Unit “Neftyanik”. Address: 625062 Tyumen, st. Yuri Semovskikh, 8/1; e-mail: iraena@mail.ru.
Gonyaev Artem Romanovich – urologist of the clinical hospital "Mother and Child". Address: 625032, Tyumen, Yuri Semovskikh str., 20; e-mail: a.gonyaev25@yandex.ru.
Boldyrev Aleksey Leonidovich – urologist, Regional Clinical Hospital No.2. Address: 625039, Tyumen, Melnikaite str., 75; e-mail: boldyrev.a.l@yandex.ru.
Petrov Daniil Ivanovich – student of the Faculty of Medicine, Tyumen State Medical University of the Ministry of Health of Russia. Address: 625023 Tyumen, st. Odessa, 54; e mail: tgmu@tyumsmu.ru.
Spirina Daria Sergeevna – student of the Faculty of Medicine, Tyumen State Medical University of the Ministry of Health of Russia. Address: 625023 Tyumen, st. Odessa, 54; e mail: tgmu@tyumsmu.ru.


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