The article discusses results of the HOPE-2 study, which have demonstrated ineffectiveness of folic acid, B6 and B12 vitamins in terms of reducing the risk of cardiovascular complications, and results of HOPE-TOO study, the results of which confirmed the need for the administration of ACE inhibitors, in particular, ramipril, in all patients with high risk of cardiovascular complications. Use of vitamin E in them, on the contrary, it is inappropriate and can be dangerous.

Keywords: vitamin E, HOPE-TOO, HOPE-2, HOPE, ramipril