Tubulo-interstitial involvement in kidney disease in patients with infective endocarditis


E.Yu. Ponomareva, M.A. Tiapkina, A.P. Rebrov

State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky, Russia, Saratov
Aim. Assessment of incidence and severity of renal tubulo-interstitial damage in patients with infective endocarditis (IE) with kidney involvement.
Methods. 41 patients with IE were included into the study. In all patients albuminuria, urine level of alfa-2-microglobulin, activity of gamma-glutamiltransferase (g-GT) – enzyme of the brush border of tubular epithelium, mitochondrial enzyme lactatdehydrogenase (LDH), as well as markers of systemic inflammation – serum C-reactive protein and circulating immune complexes concentrations were determined.
Results. Patients with IE were characterized by significant elevation of enzymuria and urine alfa-2-microglobulin level; this parameters were highest in those patients, who received aminoglicozydes or vancomycin. Signs of glomerular and tubulo-interstitial involvement correlated with intensity of systemic inflammatory responce.
Conclusion. Patients with IE are characterized with renal tubulo-interstital involvement, associated with systemic inflammatory response, glomerulonephritis and decrease of renal function.

About the Autors


Ponomareva E.Yu. – associate professor at hospital therapy department of Medical Faculty State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky, Ph.D.;

Tiapkina M.A. – assistant at hospital therapy department of Medical Faculty State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky;

Rebrov A.P. – professor, honored physician of Russian Federation, head of hospital therapy department of Medical Faculty, vice-rector on medical work and post diploma education at State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky, Ph.D


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