Changes in neurophysiological parameters in patients with uremic polyneuropathy


A.N. Fedoseev, V.V. Shestakov, I.N. Vaylin, A.S. Vaylina, V.V. Smirnov

1 FSBI "Federal Scientific Research Centre" of the Federal Medical-Biological Agency of the Russian Federation, Department of Internal Diseases FSBEI of Further Professional Education of the Institute of Advanced Training of the Federal Medical-Biological Agency of Russia; 2 SBEI HPE "Perm State Medical Academy n.a. Acad. E.A. Vagner ", Department of Neurology, Faculty of Advanced Training and Professional Retraining of Specialists; 3 SBHCI CCH № 12 of the Moscow Healthcare Department
Discusses the change in the functional activity of the peripheral nerves, as well as the characteristic features of uremic polyneuropathy in patients with end - stage renal disease. Studied 60 patients with end-stage chronic renal failure. Patients underwent clinical neurological and neuropsychological testing in the form of stimulus EMG. The regularities of the neurophysiological patterns of uremic polyneuropathy are the most frequent complications of the nervous system in patients on dialysis therapy, significantly impairing the quality of life of this group of patients. Revealed that the nature of demyelinating lesions of peripheral nerves of the lower extremities does not coincide with axonal and does not depend on it. Also shown are the characteristic features of the flow of uremic polyneuropathy. Despite the pronounced changes in innervations, significant decrease in the amplitude of M-response motor fibers, motor defect in the patients examined clinically was expressed moderately. At the same time, with a moderate reduction in sensory nerves of lower extremities in the patients examined widely represented sensitivity disorder, which is a typical feature of uremic polyneuropathy .

About the Autors


Information about the authors:
A.N. Fedoseev - Head of the Department of hemodialysis FSBI FSRC FMBA of Russia, Professor, Department of Internal Diseases FSBEI FPE IAT FMBA of Russia, MD
Shestakov V.V. - Professor, Head of Department of Neurology FATPRS SBEI HPE PSMA n.a. Acad. E.A.Vagner
Vaulin I.N. - doctor at the neurological unit SBHCI CCH № 12.
Vaulina A.S. – Doctor at the hemodialysis unit FSBI FSRC FMBA of Russia, PhD in Medical Sciences.
E-mail: alishka0110@rambler.ru
Smirnov V.V. - Professor, Head of Department of Internal Diseases FSBEI FPE IAT FMBA of Russia, MD


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