Dialyzers are optimized for hemodialysis (HD) and provide removal of a significant number of small uremic molecules, as well as medium-sized molecules with a smaller membrane-to-blood contact area. A randomized controlled trial has demonstrated that the efficacy of dialysis using Revaclear was comparable to the efficacy achieved with the use of properly sized Fresenius Medical Care's FX dialysers [1]. According to the results of a comparative clinical study of Revaclear and FX CorDiax dialyzers, the internal diameter of the Poracton membrane of the Revaclear dialyzer – 190 μm, provides effective internal filtration in standard HD with better β2-microglobulin clearance [2]. During dialysis using the Revaclear dialyzer, an effective clearance of hepcidin regulating iron metabolism, which was recently recognized as uremic toxin, was demonstrated [3].
Due to the special design of the box/collector and the hollow fiber membrane of Revaclear dialyzers, rheology and hydrodynamics created simplify the use of the dialyzer. This allows to reduce the dialysis fluid flow to the blood flow ratio without changing the dialysis dose, which in turn can help reduce the volume of water used during dialysis.
The Revaclear dialyzer and clinical results of its use are superior to the usual results observed with high-flow hemodialysis. The Revaclear dialyzer is effective and economic for a dialysis clinic and expands the possibilities of effective HD in patients with end stage renal disease (ESRD).

Keywords: HDF, urea and β2-microglobulin clearance, Revaclear dialyzer, Poracton membrane, high-flow hemodialysis