Clinical Nephrology » Distribution of HLA-antigens among patients with chronic kidney disease

Distribution of HLA-antigens among patients with chronic kidney disease

DOI: https://dx.doi.org/10.18565/nephrology.2018.3.15-20

I.R. Ramilieva, A.A. Turganbekova, Zh.K. Burkitbaev, S.A. Abdrakhmanova, D.K. Baymukasheva, E.B. Zhiburt
1 Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan; Astana, Kazakhstan; 2 FSBI "N.I. Pirogov National Medical and Surgical Center" of the Ministry of Health of the Russian Federation; Moscow, Russia

Introduction. HLA-complex causes a genetic predisposition to a number of diseases or, con-versely, is associated with resistance to certain diseases.
Objective. Evaluation of the distribution of antigen genetic polymorphism, histocompatibility of patients with end-stage renal disease and donors (healthy individuals).
Materials and methods. Patients with end-stage renal disease (3387) and donors (3646) older than 18 years were examined. A molecular genetic method using Protrans assays (Germany) for the examination of blood samples from HLA-A, B-, DRB1-loci was applied.
Results. The features of the distribution of HLA-A-, B-, DR-antigens in patients with chronic kidney disease (CKD) are shown. HLA-A*24; B*37, *40, *50, *54; DRB1 *10, *11, *12 are associated with CKD. Phenotypes with HLA-A*02, *03, *25; B*07, *35, *46; DRB1 *01, *08, *15 antigens have a protective effect.
Conclusion. A characteristic profile of the distribution of specificities of the HLA system in patients with chronic kidney disease in the Kazakhstan population was revealed.

Keywords: HLA-complex, antigens, chronic kidney disease, end-stage renal disease, renal pathology

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About the Autors

Ramilieva I.R. – Physician of the Department of Tissue Immunotyping of (HLA) of Republican State Enterprise on the Right of Economic Use "Scientific and Production Center
of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan; Astana, Kazakhstan. E-mail: ramileva_84@mail.ru
Turganbekova A.A. – Head of the Department of Tissue Immunotyping of (HLA) of Republican State Enterprise on the Right of Economic Use "Scientific and Production Center
of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan; Astana, Kazakhstan. E-mail: dr.aida@mail.ru
Burkitbaev Zh.K – PhD in Medical Science, Director of Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry
of Health of the Republic of Kazakhstan; Astana, Kazakhstan. E-mail: omninpct16@mail.ru
Abdrakhmanova S.A. – PhD in Medical Sciences, Deputy Director of Republican State En-terprise on the Right of Economic Use "Scientific and Production Center of Transfusiology"
of the Ministry of Health of the Republic of Kazakhstan; Astana, Kazakhstan. E-mail: a.saniya@mail.ru
Baymukasheva D.K. – Physician of the Department of Tissue Immunotyping of (HLA) of Re-publican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan; Astana, Kazakhstan.
Zhiburt E.B. – Doctor of Medical Sciences, Professor, Head of the Department of Transfusi-ology and Blood Transfusion Problems of the FSBI "N.I. Pirogov National Medical
and Surgical Center" of the Ministry of Health of the Russian Federation; Moscow, Russia.

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