Русский
Blood plasma cystatin c level and its relationship with the augmentation index and central arterial pressure in therapeutic patients
DOI: https://dx.doi.org/10.18565/nephrology.2018.3.31-40
I.T. Murkamilov, K.A. Aitbaev, V.V. Fomin, Zh.A. Murkamilova, I.S. Sabirov
1 Kyrgyz State Medical Academy n.a. I.K. Akhunbaev; Bishkek, Kyrgyzstan; 2 SEI HPE "Kyrgyz-Russian Slavic University n.a. the First President of the Russian Federation B.N. Yeltsin"; Bishkek, Kyrgyzstan; 3 Research Institute of Molecular Biology and Medicine at the National Center for Cardiology and Therapy of the Ministry of Health of the Kyrgyz Republic; Bishkek, Kyrgyzstan; 4 FSAEI HE " I.M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation; Moscow, Russia; 5 Center for Family Medicine № 7; Bishkek, Kyrgyzstan
Material and methods. A total of 645 therapeutic patients older than 16 years were examined, including 294 men (45.6%), women 351 (54.4%). The mean age of the examined subjects was 50.5±11.1 years. AI and CAP were measured in all patients. In addition, the blood plasma lipid spectrum, cystatin C, calcium, and uric acid levels were examined. Based on the measurement of the blood plasma cystatin C level, the glomerular filtration rate (GFR) was calculated according to the F.J. Hoek et al. (2003) formula. Depending on the plasma of cystatin C content, all subjects were divided into two groups. The first group (n=298) included patients with a cystatin C level ˂1.0 mg/l, the second group (n=347) – patients with a cystatin C level ≥1.0 mg/l.
Results. The mean age of patients (54.5±14.8 years vs. 44.1±13.4 years, p<0.05), the body mass index (27.9±5.5 kg/m2 vs. 26.5±5,2 kg/m2, p<0.05), systolic blood pressure (133±19 mm Hg vs. 124±16 mm Hg, p<0.05) and CAP (130±21 mm Hg vs. 122±17 mm Hg, p<0.05) were significantly higher in the second group compared to the first group. In the group of patients with elevated blood plasma cystatin C levels, mean values of calculated GFR (52.2±18.5 ml/min vs. 91.7±13.4 ml/min, p<0.05) and high-density lipoprotein cholesterol (HDL cholesterol) levels (1.12±0.29 mmol/L versus 1.18±0.28 mmol/L, p<0.05) were significantly lower than in the first group. In the second group, there was also a tendency to increase the degree of AI [12.6 (0.60–22.90)% versus 10.8 (-3.10-20.40)%; p=0.060)]. In the general sample, a positive correlation between systolic blood pressure levels (r=0.222, p= 0.001) and CAP (r=0.198, p=0.004) with blood plasma cystatin C levels was obtained. At the same time, the correlation of HDL cholesterol (r=-0.201, p=0.003), calcium (r=-0.349, p=0.000) levels and calculated GFR (r=-0.837, p=0.000) with blood plasma cystatin C levels was negative. Statistically significant relationship was noted only between the calculated GFR and blood plasma cystatin C levels in all groups.
About the Autors
Murkamilov I.T. – PhD in Medical Sciences, Nephrologist, Teaching Assistant at the Department of Faculty Therapy KSMA n.a. I.K. Akhunbaev; Bishkek, Kyrgyzstan.
E-mail: murkamilov.i@mail.ru.
Aitbaev K.A. – Doctor of Medical Sciences, Professor, Head of the Laboratory of Pathological Physiology of the Research Institute of Molecular Biology and Medicine at the National Center for Cardiology and Therapy of the Ministry of Health of the Kyrgyz Republic; Bishkek, Kyrgyzstan.
Fomin V.V. – Doctor of Medical Sciences, Professor, Head of the Department of Faculty Therapy № 1, Director of the Clinic of Faculty Therapy n.a. V.N. Vinogradov, Vice-Rector
for Research and Clinical Work of the FSAEI HE "I.M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation; Moscow, Russia.
Murkamilova Zh.A. – Nephrologist, Center for Family Medicine № 7; Bishkek, Kyrgyzstan.
Sabirov I.S. – Doctor of Medical Sciences, Professor, Head of the Department of Therapy №2, SEI HPE "Kyrgyz-Russian Slavic University n.a. the First President of the Russian Federation B.N. Yeltsin"; Bishkek, Kyrgyzstan.
