Purpose. Despite the success of hemodialysis therapy, one of the unresolved problems remains the problem of the biocompatibility of dialysis membranes, which leads to a deterioration in the results of treatment, and also promotes the development of resistance to erythropoietin-stimulating drugs in the treatment of anemia.
Material and methods. An open prospective study on the effect of vitamin E-coated dialysis membranes on the inflammation level and the index of resistance to erythropoietin-stimulating agents (ERI) enrolled for the period of 3 months 30 patients who received hemodialysis for at least 3 months. Interleukin-6 (IL-6), C-reactive protein, iron metabolism, albumin, and prealbumin levels were determined every month.
Results. During the treatment of patients using vitamin E-coated polysulfone dialysis membranes, the IL-6 level was statistically significantly reduced, from 9.4±13.5 to 1.3±2.1 pg/ml (P<0.001). The parameters of iron metabolism, albumin, prealbumin and C-reactive protein levels did not change significantly. Generally, ERI in the group did not change significantly, but in patients with initially high ERI it decreased from 12.5±2.2 to 10.7±1.2 IU/ kg/week/g (P<0.05).
Conclusion. The use of vitamin E-coated polysulfone dialysis membranes is advisable for patients with high ERI to treat anemia and reduce inflammation.

Keywords: anemia, hemodialysis, inflammation, vitamin E