Сlinical and pathological correlation of glomerulopathy in patients living in the Kyrgyz Republic

DOI: https://dx.doi.org/10.18565/nephrology.2019.2.32-38

D.A. Ayipova, N.A. Beishebaeva, K.A. Uzakbaev, R.R. Kaliev

1) National Center for Cardiology and Therapy n.a. Acad. Mirsaid Mirrakhimov of the Ministry of Health of the Kyrgyz Republic, Department of Nephrology, Bishkek, Kyrgyz Republic; 2) National Center for Maternal and Child Health, Bishkek, Kyrgyz Republic; 3) I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic
Objective. Creation of a unified register of renal biopsies of the Kyrgyz Republic (RBKR). Establishment of relationship between morphological and clinical manifestations of glomerulopathy.
Material and methods. The study included 245 patients who underwent a study of renal tissue samples obtained in vivo by percutaneous biopsy from 2015 to 2019. All patients underwent a complex of general clinical, biochemical, immunological, instrumental and morphological studies.
Results. In the pediatric cohort, 41 (41.8%) patients with hematuria combined with nephrotic proteinuria were followed-up, and it was the maximum number of all examined children. Patients with nephritic and nephrotic syndromes were detected with the same frequency in 27 (27.5%) and 22 (22.4%) patients, respectively. Isolated urinary syndrome was detected only in 8 (8.16%) patients. In the adult cohort, nephritic-range proteinuria was more often recorded – in 96 (65.3%) patients. Isolated urinary syndrome was observed in 30 (20.4%) patients. It should be emphasized that the incidence of all clinical manifestations (proteinuria with and without hematuria) compared with children differed.
Conclusion. The most common variants of glomerular lesion in adults includrd membranous glomerulonephritis (MN [38%]) and immunoglobulin A nephropathy (IgAN; 29.2%), whereas in children IgAN and the minimal change glomerulonephritis dominated, in 20.4 and 19.3%, respectively.
Keywords: morbidity, renal biopsy, epidemiology, register

About the Autors

Ayipova D.A. – Researcher at the Department of Nephrology, National Center for Cardiology and Therapy n.a. Acad. M. Mirrakhimov; Bishkek, Kyrgyzstan. E-mail: dinaralievna@gmail.com
Beishebaeva N.A. – PhD in Medical Sciences, Head of the Department of Nephrology, National Center for Cardiology and Therapy n.a. Acad. M. Mirrakhimov; Bishkek, Kyrgyzstan. E-mail: beishebaevanasira@gmail.com
Uzakbaev K.A. – PhD in Medical Sciences, Professor, Director of the National Center for Mater-nal and Child Health; Bishkek, Kyrgyzstan.
Kaliev R.R. – PhD in Medical Sciences, Professor at the Department of Faculty Therapy, I.K. Akhunbaev Kyrgyz State Medical Academy; Bishkek, Kyrgyzstan. E-mail: karys2002@mail.ru

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