Objective. Assessment of renal dysfunction in patients with spondyloarthritis (SpA) who receive various long-term anti-inflammatory therapy during follow-up.
Material and methods. The glomerular filtration rate (GFR), α1-microglobulin and urine albumin levels in patients with SpA who received various long-term anti-inflammatory therapy were evaluated initially and after 12 months of follow-up.
Results. A decrease in GFR less than 90 ml/min/1.73 m2 was detected in 64 (49.2%) patients with SpA who took non-steroidal anti-inflammatory drugs (NSAIDs) with glucocorticosteroids (GCS), in 37 (52.8%) patients who took only NSAIDs (χ2=0.01, p=0.44). Tubular dysfunction and increased urinary albumin excretion were detected in 86.9% of patients taking NSAIDs alone and in 36.2% of patients taking NSAIDs and GCS (β12=4.93; p=0.01). After 12 months of follow-up, in patients with SpA who took NSAIDs and GCS, GFR was higher compared to baseline value: 96 (89–109) and 88 (80–104) ml/min, respectively (p=0.04). In patients who took only NSAIDs, GFR after 12 months of follow-up was 85.5 (77–104) ml/min, with initial GFR 87.5 (75.5–98) ml/min (p>0.05). A decrease in GFR after 12 months of follow-up was more frequently detected in patients who took only NSAIDs than in patients who took NSAIDs and GCS (61.7% and 47.3%, respectively, χ2 with Yates correction=3.4, p=0.03).
Conclusion. SpA patients suffered from renal dysfunction of varying severity. At the same time, in patients who received a combination therapy including NSAIDs and GCS, renal dysfunction was less pronounced.

Keywords: spondyloarthritis, tubular and glomerular dysfunction, nonsteroidal anti-inflammatory drugs, glucocorticosteroids