Thrombotic microangiopathy (TMA) is a clinico-morphological syndrome belonging to the spectrum of diseases with endothelial damage as an etiological factor. The article discusses issues of classification, features and pathogenesis of secondary TMA, strategies for modern diagnostics and treatment. The clinical picture of secondary TMA has no specific features. The criteria for making a clinical diagnosis of TMA include the presence of at least two symptoms: thrombocytopenia and microangiopathic hemolytic anemia. The development of secondary TMA is associated with a wide range of different diseases and conditions discussed in this review. Their timely detection is the most important, because it greatly improves the prognosis. Timely diagnosis and treatment of TMA associated with pregnancy demonstrate good results. On the other hand, the prognosis for TMA associated with hematopoietic stem cell transplantation and for TMA associated with chemotherapy remains unfavorable. Currently there are no generally accepted standards for the treatment of secondary TMA.

Keywords: primary thrombotic microangiopathy, secondary thrombotic microangiopathy