Clinical Nephrology » Ezetimibe in chronic kidney disease: an effect on the risk of developing cardiovascular and cerebral complications

Ezetimibe in chronic kidney disease: an effect on the risk of developing cardiovascular and cerebral complications

DOI: https://dx.doi.org/10.18565/nephrology.2020.3.37-44

I.Т. Murkamilov, I.S. Sabirov, V.V. Fomin, Zh.A. Murkamilova, F.A. Yusupov, N.A. Redzhapova, Z.R. Rayimzhanov
1) Kyrgyz State Medical Academy named after I.K. Akhunbaev; Bishkek, Kyrgyzstan; 2) Kyrgyz Russian slavic university; Bishkek, Kyrgyzstan; 3) FSAEI HE First Moscow State Medical University named after I.M. Sechenov; Moscow, Russia; 4) Osh State University; Osh, Kyrgyzstan

The article discusses the effectiveness and safety of lipid-lowering therapy in patients with cardiovascular and renal diseases. Attention is focused on an inhibitor of cholesterol absorption in the small intestine – ezetimibe. Data on the hypolipidemic and anti-inflammatory effects of ezetimibe and its combination with statins are summarized. Ezetimibe has been shown to have a good safety profile, significantly reducing cardiovascular and cerebral risk, as well as the progression of chronic kidney disease.

Keywords: cardiovascular and cerebral complications, risk factors, renal dysfunction, low density lipoprotein cholesterol, ezetimibe, statins, C-reactive protein

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About the Autors

Ilkhom T. Murkamilov – PhD in Medical Sciences, Nephrologist, Deputy Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev KSMA; Senior Lecturer of the Department of Therapy № 2in the specialty "General Medicine, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan. E-mail: murkamilov.i@mail.ru, ORCID: org / 0000-0001-8513-9279
Ibragim S. Sabirov – Doctor of Medical Science, Professor, Head of the Department of Therapy № 2 in the Specialty "Medical Care" Kyrgyz Russian Slavic University n.a. the First President of Russia B.N. Yeltsin; Bishkek, Kyrgyzstan. E-mail: sabirov_is@mail.ru
Viktor V.Fomin - Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy № 1, Vice-Rector for Clinical Work and Postgraduate Professional Education, Sechenov First MSMU; Moscow, Russia. E-mail: fomin_vic@mail.ru, ORCID: org / 0000-0002-2682-4417
Zhamila A. Murkamilova – Correspondence Post-Graduate Student at the Department of Therapy № 2 in the specialty "General Medicine", KRSU, Bishkek; e-mail: murkamilovazh.t@mail.ru ORCID: org / 0000-0002-7653-0433
Furkat A. Yusupov – Doctor of Medical Sciences, Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Faculty of Medicine, Osh State University; Chief Neurologist of the Southern Region of Kyrgyzstan, Osh, Kyrgyzstan. E-mail: furcat_y@mail.ru, ORCID: org / 0000-0003-0632-6653
Nodira A. Regzhapova – Postgraduate Student at the Department of Neurology and Psychiatry, Faculty of Medicine, Osh State University; Osh, Kyrgyzstan.
E-mail: nredzhapova@mail.ru
Zafarbek R. Rayimzhanov – correspondence graduate student of I.K. Akhunbaev KSMA, Kyrgyz-Russian Slavic University; Bishkek, Kyrgyzstan. E-mail: rzrmam@mail.ru; ORCID:org/0000-0001-5746-6731

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