Русский
Renal status, blood d-dimer and procalcitonin levels in COVID-19
DOI: https://dx.doi.org/10.18565/nephrology.2020.4.43-50
I.T. Murkamilov, K.A. Aitbaev, V.V. Fomin, I.O. Kudaibergenova, T.I. Maanaev, Zh.A. Murkamilova, F.A. Yusupov
1) I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan; Bishkek, Kyrgyzstan; 2) Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan; 3) Scientific Research Institute of Molecular Biology and Medicine; Bishkek, Kyrgyzstan; 4) Sechenov First Moscow State Medical University, Moscow, Russia; 5) National Hospital of the Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; 6) Osh State University, Osh, Kyrgyzstan
Material and methods: The study included 123 patients diagnosed with COVID-19 and pneumonia. The indices of the estimated glomerular filtration rate (eGFR) were considered according to the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and MDRD (Modification of Diet in Renal Disease) formulas. The creatinine clearan the concentration of creatinine, D-dimer, and procalcitonin levels were determined.
Results. The median and interquartile eGFR values according to the CKD-EPI and MDRD formulas were 80.0 (68.0; 95.0) and 78.0 (67.0; 94.0) ml/min, respectively. A decrease in GFR <60 ml/min according to the CKD-EPI, MDRD and Cockcroft-Gault formulas was found in 14, 11 and 12 patients with COVID-19, respectively. The creatinine clearance according to the Cockcroft-Gault formula was 85.0 (68.0; 102.0) ml/min. Proteinuria was noted in 48 (39.0%) patients with COVID-19. A negative relationship between the blood procalcitonin level and GFR calculated using the MDRD formula (r=-0.307; P<0.05) and creatinine clearance using the Cockcroft-Gault method (r=-0.313; P<0.05) was found. A direct dependence of proteinuria on the blood D-dimer (r=0.437; P<0.05) and procalcitonin (r=0.409; P<0.05) concentration was shown. The blood procalcitonin level positively correlated with the urea concentration (r=0.448; P<0.05) and blood residual nitrogen (r=0.399; P<0.05).
Conclusion. A slight decrease in renal function was detected in 26.8% of patients with COVID-19, a moderate decrease – in 4.1%, a significant decrease – in 3.2%, and renal failure - in 4.1%. Proteinuria was recorded in 39.0% of patients with COVID-19. An D-dimer concentration was found in 47.9% of patients with COVID-19, and increase in the procalcitonin level - in 49.5%. The laboratory predictor of deterioration in renal function in patients with COVID-19 was the blood procalcitonin level. The risk of developing proteinuria was closely related to the blood D-dimer concentration.
About the Autors
Ilkhom T. Murkamilov – Cand. Sci. (Med.), Nephrologist, Deputy Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev KSMA; Senior Lecturer of the Department of Therapy № 2in the specialty “General Medicine, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan. E-mail: murkamilov.i@mail.ru,
ORCID: org / 0000-0001-8513-9279
Kuvanych A. Aitbaev – Dr.Sci. (Med.), Professor, Head of the Laboratory of Pathological Physiology, Research Institute of Molecular Biology and Medicine; Bishkek, Kyrgyzstan. Email: kaitbaev@yahoo.com; ORCID: org / 0000-0003-4973-039X
Viktor V. Fomin - Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy № 1, Vice-Rector for Clinical Work and Postgraduate Professional Education, Sechenov First MSMU; Moscow, Russia. E-mail: fomin_vic@mail.ru, ORCID: org / 0000-0002-2682-4417
Indira O.Kudaibergenova - Dr.Sci. (Med.), Professor, Rector of the I.K. Akhunbaev KSMA; Bishkek; Kyrgyzstan; e-mail: k_i_o2403@mail.ru. ORCID: org / 0000-0003-3007-8127
Toktobay I. Maanaev - Cand. Sci. (Med.), Chief Physician of the National Hospital of the Ministry of Health of the Kyrgyz Republic; Bishkek, Kyrgyzstan; 031262-10-14
Zh. A. Murkamilova - Correspondence Post-Graduate Student at the Department of Therapy № 2 in the specialty “General Medicine”, KRSU, Bishkek;
e-mail: murkamilovazh.t@mail.ru ORCID: org / 0000-0002-7653-0433
Furkat A. Yusupov - Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Faculty of Medicine, Osh State University; Chief Neurologist of the Southern Region of Kyrgyzstan, Osh, Kyrgyzstan. E-mail: furcat_y@mail.ru, ORCID: org / 0000-0003-0632-6653
