Nephroprotective effects of sodium-glucose linked transporter-2 inhibitors


DOI: https://dx.doi.org/10.18565/nephrology.2020.4.75-79

B.T. Daminov, Sh.S. Abdullaev, O.N. Sharapov

1) Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; 2) Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Tashkent, Uzbekistan
The article presents data on the mechanisms and clinical significance of the nephroprotective effect of sodium-glucose linked transporter-2 inhibitors (glyflozines). The effects associated with the influence of representatives of this pharmacological group on the glomerular filtration rate, glycemic level, diuresis, ketogenesis and other factors are discussed. The results of recent experimental and clinical studies aimed at studying certain aspects of the nephroprotective effect of SGLT2 inhibitors in type 2 diabetes mellitus and other pathological conditions are analyzed.
Keywords: diabetes mellitus, oral hypoglycemic drugs, sodium-glucose linked transporter-2 inhibitors, chronic kidney disease, diabetic nephropathy, nephroprotection
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About the Autors

Botir T. Daminov – Dr. Sci. (Med.), Professor at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute; Director of the Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation; Tashkent, Uzbekistan. E-mail: nefrologiya2019@mail.ru
Sherzod S. Abdullaev – Dr. Sci. (Med.), Associate Professor at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; e-mail: dr.sherzod@rambler.ru. ORCID: 0000-0003-0640-5976
Olimkhon N. Sharapov – Doctoral Student at the Department of Faculty Internal Diseases, Occupational Pathology, MFT, Hospital Internal Diseases and PID, Tashkent Pediatric Medical Institute; Nephrologist at the Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation; Tashkent, Uzbekistan; e-mail: olimkhon@gmail.com. ORCID: 0000-0003-2452-416X

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