Русский
Remote monitoring of kidney transplant recipients
DOI: https://dx.doi.org/10.18565/nephrology.2023.2.11-18
Ivanova E.S., Kotenko O.N., Kargalskaya I.G., Vinogradov V.E., Berdinsky V.A., Artyukhina L.Yu., Frolova N.F.
Moscow City Scientific and Practical Center for Nephrology and Transplanted Kidney Pathology, City Clinical Hospital № 52 of the Moscow Healthcare Department, Moscow, Russia
Material and methods. A retrospective study based on the results of remote monitoring and questionnaires returns of 52 RTRs followed-up at the Scientific and Practical Center for Nephrology and Transplanted Kidney Pathology, City Clinical
Hospital № 52 using the TRANSPLANTNET service from 2019 to 2022 was conducted.
Results. The patients differed in terms of the period of returns to the questionnaires: in early-term patients after renal allotransplantation (RAT) (group 1), the response period was shorter and amounted to 9.9 [6.3; 21.1] months compared with late-term patients after RAT (group 2) – 18.0 [14.2; 31.9] months (P<0.05). In group 1, symptoms of trembling in the limbs or throughout the body, as well as irritability and aggression, were detected 2 times more often. These symptoms have been associated with blood tacrolimus levels. So, in the presence of trembling in the limbs or throughout the body, the mean tacrolimus C0 level was 11.3±3.4 ng/ml, and in the absence of tremors, it was 7.8±2.5 ng/ml (P<0.05). The mean tacrolimus
C0 level in patients with irritability/aggression was 11.2±3.0 ng/ml, without these symptoms – 7.9±2.9 ng/ml (P<0.05).
Conclusion. Remote monitoring makes it possible to detect serious symptoms in patients after RAT, which can lead to the development of RT dysfunction if left untreated. The possibility of feedback from patients allows to give timely recommendations for additional examination and correction of ongoing therapy to eliminate these symptoms.
About the Autors
Ekaterina S. Ivanova – Cand.Sci. (Med.), Nephrologist, Nephrology Department № 1, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182, e-mail: katerineiv@mail.ru. ORCID: https://orcid.org/0000-0001-7407-5695.
Oleg N. Kotenko – Cand.Sci. (Med.), Chief External Expert in Nephrology of the Moscow Healthcare Department, Head of the Scientific and Practical Center for Nephrology and Transplanted Kidney Pathology, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182;
e-mail: olkotenko@yandex.ru. ORCID: https://orcid.org/0000-0001-8264-7374
Irina G. Kargalskaya – Analyst at the Educational Department, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; email: kargalska@yandex.ru.
Vladimir E. Vinogradov – Head of the Consultative and Diagnostic Nephrology Department, City Clinical Hospital № 52 of the Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: vino-gradoff@yandex.ru. ORCID: https://orcid.org/0000-0002-2499-4770.
Vitaly A. Berdinsky – Head of the Nephrology Department № 4, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow,
123182; e-mail: vitaly.berdinsky@yandex.ru. https://orcid.org/0000-0001-5966-0415.
Lyudmila Yu. Artyukhina – Cand.Sci.(Med.), Head of the Nephrology Department № 1, City Clinical Hospital № 52 of the Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: arlyu-1404@yandex.ru. ORCID: https://orcid.org/0000-0003-3353-1636.
Nadiya F. Frolova – Cand. Sci (Med.), Deputy Chief Physician for Nephrological Care, City Clinical Hospital № 52 of the Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: nadiya.frolova@yandex.ru. ORCID: http://orcid.org/0000-0002-6086-5220.
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