Diagnostic significance of biomarkers detection in blood and urine of patients with systemic lupus erythematosus


A.P. Rebrov, N.B. Zakharova, A.N. Oksen'chuk, O.G. Karpova, D.A. Patrikeeva, E.B. Popikhalova

SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
Aim. Study of change of dynamics of levels of biomarkers in blood seruma and urine in patients with systemic lupus erythematosus (SLE).
Methods. 40 patients with SLE were included into the study. Levels of interleukins, tumor necrosis factor-alpha (TNF-α), monocyte chemotaxic protein type 1 (МСР-1), vessel-endothelial growth factor (VEGF) in blood serum and urine were determined by immunoenzyme analysis.
Results. Levels of VEGF, МСР-1, interleukin-6 (IL-6) were elevated in blood serum; levels of VEGF, IL-6 and IL-8 – in the urine. Biomarkers blood and urine levels did not differed significantly according to SLE activity.
Conclusion. Biomarkers determination in blood and urine can help monitoring of clinical evolution and activity of systemic lupus erythematosus.

About the Autors


Rebrov A.P., MD, PhD, professor, head of hospital therapy chair of medical faculty SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
E-mail: andreyrebrov@yandex.ru
Zakharova N.B., MD, PhD, professor, head of Central Research Laboratory of SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
Oksen'chuk A.N., assistant professor of hospital therapy chair of medical faculty SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
Karpova O.G., assistant professor of hospital therapy chair of medical faculty SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
Patrikeeva D.A., assistant professor of hospital therapy chair of medical faculty SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation
Popikhalova E.B., PhD, senior research officer of Central Research Laboratory of SBEU HPE Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Healthcare of Russian Federation


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