Place and role of plasma purification technologies in treatment of severe forms of granulematosis with polyangiitis in ICU


DOI: https://dx.doi.org/10.18565/nephrology.2021.2.47-55

M.S. Vetsheva, O. L. Podkorytova, K.E. Loss, O.N. Kotenko

1) Department of Anesthesiology and Reanimatology, Faculty of General Medicine, Sechenov University, Moscow, Russia; 2) City Clinical Hospital № 52 of the Moscow Healthcare Department, уMoscow, Russia
ANCA-associated systemic vasculitis is characterized by overproduction of ANCA autoantibodies with specificity for myeloperoxidase or proteinase-3, affecting small and medium-sized vessels with the development of necrotizing vasculitis. Pathogenetic therapy includes the use of glucocorticosteroids, cytostatics, and monoclonal antibodies. In case of the development of life-threatening conditions, however, individual approaches to treatment should be used; drug therapy should be combined with extracorporeal methods: hemodialysis, therapeutic plasma exchange and double filtration plasmapheresis in the optimal combination for the patient and the optimal time of their use.
Keywords: double filtration plasmapheresis (DFPP), therapeutic plasma exchange (TPE), ANCA-associated vasculitis
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About the Autors

Maria S. Vetsheva – Dr. Sci. (Med.), Professor; Professor at the Department of Anesthesiology and Emergency Medicine, Faculty of General Medicine, Sechenov University; Moscow, Russia; e-mail: rimsho@mail.ru
Olga L. Podkorytova – Cand. Sci. (Med.), Head of the Intensive Care Unit № 2, City Clinical Hospital № 52 of the Moscow Healthcare Department; Moscow, Russia;
e-mail: o-podkorytova@yandex.ru.
Karina E. Loss – Intensivist at the Intensive Care Unit № 2, City Clinical Hospital № 52 of the Moscow Healthcare Department; Moscow, Russia; e-mail: karina1512@mail.ru.
Oleg N. Kotenko – Cand. Sci. (Med.); Head of the Moscow Scientific and Practical Center for Nephrology and Transplanted Kidney Pathology, City Clinical Hospital № 52
of the Moscow Healthcare Department; Chief External Expert in Nephrology of the Moscow Healthcare Department; Moscow, Russia; e-mail: olkotenko@yandex.ru.


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