Squamous cell cancer in renal transplant recipients: a real threat?


DOI: https://dx.doi.org/10.18565/nephrology.2022.2.69-72

D.V. Perlin, I.N. Dymkov, Sh.N. Shamkhalov, A.D. Perlina, P.A. Kulikov

1) Volgograd Regional Uronephrological Center, Volgograd Region, Volzhsky, Russia; 2) M.F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia
Immunosuppressive therapy after solid organ transplantation significantly increases the risk of developing cancer compared with the general population. We present our own observation of a severe course of metastatic squamous cell skin cancer in a patient with satisfactory graft function 10 years after cadaveric kidney transplantation, who standard 3-component immunosuppression. Despite surgical treatment and a course of radiation, the disease was accompanied by rapid progression and death. Long-term immunosuppressive therapy after kidney transplantation significantly increases the likelihood of developing malignant skin tumors. However, the risk increases significantly over time. Therefore, dermatological examinations should be included in the management protocol for renal transplant recipients in order to detect the disease earlier, with particular attention to patients with more than ten years of immunosuppression. If squamous cell skin cancer is confirmed, continued immunosuppressive therapy is associated with a high risk of progression and fatal outcome of the disease.
Keywords: skin neoplasms, squamous cell carcinoma, immunosuppression, kidney transplantation
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About the Autors

Dmitry V. Perlin – Dr.Sci. (Med.), Professor, Chief Physician of the Volgograd Regional Uronephrological Center, Volgograd, Russia; e-mail: dvperlin@mail.ru ORCID: https://orcid.org/0000-0002-4415-0903
Ivan N. Dymkov – Cand. Sci. (Med.), Deputy Chief Physician of the Volgograd Regional Uronephrological Center, Volgograd, Russia ORCID: https://orcid.org/ 0000-0002-1935-9801
Shamil N. Shamkhalov – Urologist, Department of Urology, Volgograd Regional Uronephrological Center, Volgograd, Russia ORCID: https://orcid.org/0000-0002-5302-2217
Anastasia D. Perlina – Dermatovenereologist, Department of Telemedicine Technologies, M.F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia ORCID: https://orcid.org/0000-0002-0629-1270
Pavel A. Kulikov – Urologist, Department of Urology, Volgograd Regional Uronephrological Center, Volgograd, Russia ORCID: https://orcid.org/0000-0002-1388-4242


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