Therapy for immunoglobulin А-nephropathy: what along with immunosuppression?


DOI: https://dx.doi.org/10.18565/nephrology.2022.4.43-48

Bobkova I.N., Kamyshova E.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Immunoglobulin-A nephropathy (IgAN) is the most common form of chronic glomerulonephritis in the world. Unlike other glomerulopathies, which are clinically manifested by episodes of nephrotic and/or acute nephritic syndromes, IgAN in most cases has few symptoms, and the decrease in glomerular filtration rate occurs gradually. The basis of IgAN treatment is individually optimized maintenance therapy aimed at correcting blood pressure, reducing proteinuria, eliminating or minimizing the impact of modifiable risk factors for the progression of chronic kidney disease. This review focuses on modern IgAN maintenance therapy, highlighting both traditional and new directions, and provides a critical analysis of their effectiveness.
Keywords: sodium-glucose cotransporter type 2 inhibitor, blockade of the renin-angiotensin-aldosterone system, ey words: immunoglobulin-A nephropathy, maintenance therapy, nephroprotection
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About the Autors

Irina N. Bobkova – Dr. Sci. (Med.), Professor at the Department of Internal, Occupational Diseases and Rheumatology, Institute of Clinical Medicine n.a. N.V. Sklifosovsky,
I.M. Sechenov First Moscow State Medical University (Sechenov University). Address: Bldg 4, 11 Rossolimo st., Moscow, 119435. e-mail: bobkova_i_n@staff.sechenov.ru. ORCID: 0000-0002-8007-5680.
Elena S. Kamyshova – Cand.Sci. (Med.), Associate Professor at the Department of Internal, Occupational Diseases and Rheumatology, Institute of Clinical Medicine n.a. N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University (Sechenov University).. Address: Bldg 4, 11 Rossolimo st., Moscow, 119435. e-mail: kamyshova_e_s@staff.sechenov.ru. ORCID: 0000-0002-1823-0125


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