Русский
Hemostasis system markers (coagulation factors) and left ventricular geometry in proteinuric variants of chronic kidney disease
DOI: https://dx.doi.org/10.18565/nephrology.2024.4.23-32
Murkamilov I.T., Aitbaev K.A., Fomin V.V., Yusupov F.A., Yusupova T.F., Yusupova Z.F., Duysheeva G.K., Khakimov Sh.Sh., Solizhonov Zh.I., Ymankulov D.S.
1) Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyzstan; 2) Salymbekov University, Bishkek, Kyrgyzstan; 3) Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan; 4) Sechenov University, Moscow, Russia; 5) Osh State University, Osh, Kyrgyzstan; 6) Kazan State Medical University, Kazan, Russia; 7) Green Clinic Medical Center, Bishkek, Kyrgyzstan
Material and methods. The study involved 612 patients with CKD and proteinuria who did not receive renal replacement therapy. The mean age was 38,1±12,7 years. The patients were divided into 2 subgroups depending on the fibrinogen level: the first (n=201) included patients with normal fibrinogen values (<4,0 g/L), the second (n=411) – with elevated levels (>4,0 g/L).
Results. Patients with hyperfibrinogenemia (HF) had significant deviations in laboratory parameters: lower levels of hemoglobin (Hb), erythrocytes, lymphocytes and color index of erythrocytes, as well as elevated levels of leukocytes and monocytes. In this group, significant changes in the levels of albumin, total protein, total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG), calcium and sodium were also found. The C-reactive protein level was elevated more often in patients with HF. In the HF group, higher rates of daily proteinuria and a decrease in the estimated glomerular filtration rate (EGR) were observed. The frequency of stable coronary artery disease in this group was higher (26,5% vs. 13,9%; p<0,05). The prevalence of LV hypertrophy (LVH) was 58,2% in individuals with HF. Eccentric LVH was more common in patients with normal fibrinogen levels (64,5% vs. 48,5%; p<0,05), while concentric LVH was higher in patients with HF (51,5% vs. 35,5%; p<0,05). It was found that blood fibrinogen level was closely associated with BMI, diastolic blood pressure, heart rate, Hb level, red blood cell count, total cholesterol, LDL, TG, creatinine, estimated GFR, LV myocardial mass and LV myocardial mass index. Activated recalcification time was closely related to Hb and platelet levels.
Conclusion. In patients with proteinuric variants of CKD and HF, laboratory predictors of renal failure and cardiovascular complications are identified. In HF, the prevalence of concentric LVH increases. A significant relationship was found between blood fibrinogen level and traditional cardiovascular and renal risk factors.
About the Autors
Ilkhom T. Murkamilov – Dr.Sci. (Med.), Associate Professor at the Department of Faculty Therapy, KSMA named after I.K. Akhunbaev; Director of the multidisciplinary medical center «Doc university clinic», Salymbekov University. Address: 92 Akhunbaev St., Bishkek, 720020. 92; Tel.: (+996) 557-221-983; E-mail: murkamilov.i@mail.ru.
ORCID: https://orcid.org/0000-0001-8513-9279 .
Kubanych A. Aitbaev – Dr.Sci. (Med.), Professor, Head of the Department of Pathological Physiology, Research Institute of Molecular Biology and Medicine. Address: 3 T. Moldo St., Bishkek, 720040; tel.: (+996) 555-758-476; e-mail: aitbaev.kuban1940@gmail.com. ORCID: https://orcid.org/0000-0003-4973-039X.
Viktor V. Fomin – Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy No. 1,
N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities, Sechenov University. Address: 2 Bolshaya Pirogovskaya St., Moscow, 119991;
tel.: (495) 609-14-00 ext. 2142; e-mail: fomin_vic@mail.ru. ORCID: https://orcid.org/0000-0002-2682-4417.
Furkat A. Yusupov – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 990-999-291; E-mail: furcat_y@mail.ru. ORCID: https://orcid.org/0000-0003-0632-6653.
Tursunoy F. Yusupova – Clinical Resident at the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University. Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938; e-mail: yusupova_tursunoy_f@mail.ru. ORCID: https://orcid.org/0000-0002-8502-2203.
Zulhumor F. Yusupova – 4th-year Student at the Faculty of Medicine, Osh State University. Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938;
e-mail: zulkhumor.yusupova.f_05@mail.ru. ORCID: https://orcid.org/0000-0001-7621-1128.
Gulzat K. Duysheeva – Teaching Assistant of the Department of Faculty Therapy, KSMA named after. I.K. Akhunbaev. Address: 92 Akhunbaev str., Bishkek, 720020;
tel.: (+996) 770-252-528; e-mail: guzyu_88@mail.ru.
Shavkat Sh. Khakimov – Head of the Department of Resuscitation, Therapy and Diagnostics, Salymbekov University. Address: 144 Bokonbaev str., Bishkek, 720040, tel.: (+996) 551-660-013; e-mail: hakimovshaki13@gmail.com. ORCID: https://orcid.org/0009-0004-0437-0188.
Zhaloliddin I. Solizhonov – 6th-year student at the Faculty of Medicine, Kazan State Medical University. Address: 49 Butlerov str., Kazan, 420012; tel.: (+495) 967-4690-0438; e-mail: jaloliddinsolijonov44@gmail.com. ORCID: https://orcid.org/0009-0003-0078-0609.
Daniyar S. Ymankulov – Researcher, Plastic Surgeon, Green Clinic. Address: 118 Isanov str., Bishkek, 720040; tel.: (+996) 551-196-991; e-mail: ymankulov9595@mail.ru. ORCID: https://orcid.org/0009-0000-4975-1196
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