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Personalization of renal replacement therapy and its effect on survival of patients with stage 5 chronic kidney disease aged 60 and older
DOI: https://dx.doi.org/10.18565/nephrology.2024.4.38-44
Kurylovich K.A., Komissarov K.S., Krasko O.V., Kamisarau S.I., Ilyinchyk А.V., Prylutski S.V., Zhaholkin Y.Y.
1) 1st City Clinical Hospital, Minsk, Republic of Belarus; 2) Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Minsk, Republic of Belarus; 3) United Institute of Informatics Problems of the National Academy of Sciences of Belarus, Minsk, Republic of Belarus; 4) 16th City Children's Polyclinic, Minsk, Republic of Belarus; 5) Minsk Order of the Red Banner of Labor Regional Clinical Hospital, Minsk Region, Republic of Belarus; 6) Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus
Materials and methods. The historical control group (HCG) (237 patients) received a standard dialysis regimen, while the experimental group (EG) (62 patients) received ATOs (conservative treatment, palliative, incremental, or standard dialysis regimens).
Results. Survival on the 90th day was 73.4±3% in the HCG, 84.4±4.8% in the EG, on the 365th day: 51.4±3.4% in the HCG, 69.6±6.9% in the EG. Evaluation of the adverse outcome risk reduction showed that treatment with ATOs reduced the risk of adverse outcome by 48 (95% confidence interval 12–69)%.
Conclusion. Due to the effectiveness of ATOs, it is necessary to consider the possibility of their inclusion in clinical protocols for the treatment of patients.
About the Autors
Krystsina A. Kurylovich – Nephrologist, Hemodialysis Department, 1st City Clinical Hospital. Address: 64 Nezavisimosti Ave, Minsk, 220013; Tel.: +3 (7544) 740-32-95;
e-mail: khruns89@gmail.com. ORCID: 0000-0002-9112-4863
Kirill S.Komissarov – Cand.Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko st., Minsk, 220087; tel.: +3 (7517) 277-20-35, +3 (7529) 680-70-97;
e-mail: kirill_ka@tut.by. ORCID: 0000- 0002-2648-0642
Olga V. Krasko – Cand.Sci.(Tech.), Leading Researcher, Bioinformatics Laboratory, United Institute for Informatics Problems of the National Academy of Sciences of Belarus. Address: 6 Surganov St., Minsk, 220012; tel.: + 3 (7529) 707-88-03; e-mail: krasko@newman/bas-net.by. ORCID: 0000-0002-4150-282X
Siarhei I. Kamisarau – Pediatrician, 16th City Children's Polyclinic. Address: 45 Odoevsky st., Minsk, 220074; tel.: +3 (7517) 304-33- 55, +3 (7544) 547-48-47; e-mail: serge.kom142@gmail.com. ORCID: 0009-0003-2966-3780
Aksana V. Ilyinchyk – Nephrologist, Head of the Hemodialysis Department, 1st City Clinical Hospital. Address: 64 Nezavisimosti Ave, Minsk, 220013; tel.: +3 (7517) 379-63-39, +3 (7529) 645-07-77; e-mail: i_o_v@tut.by. ORCID: 0009-0006-3243-9503
Siarhei V. Prylutski – Nephrologist, Head of the Department of Hemodialysis with Extracorporeal Detoxification Methods, Minsk Order of the Red Banner of Labor Regional Clinical Hospital. Address: Borovlyansky village council, 201 near the Lesnoy agricultural complex, Minsk district, Minsk region, 223040; tel.: +3 (7517) 265- 48-64, + 3 (7544) 787-03-40; e-mail: priluckii.s@mokb.by. ORCID: 0009-0004-5174-1893
Yauheni Y. Zhaholkin – Nephrologist, Head of the Hemodialysis and Nephrology Department, Mogilev Regional Clinical Hospital. Address: 12 Byalynitsky-Biruli Street, Mogilev, 212026; tel.: +3 ( 7522) 63-86-86, +3 (7529) 648-13-64, e-mail: Zhagolkin69@mail.ru. ORCID: 0009-0003-5441-9018
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