Plasmapheresis in controlling of the severity of ischemia-reperfusion damage of renal transplant

A.V. Vatazin, A.A. Siniutin, A.B. Zul'karnaev, R.O. Kantaria, M. Krstich

State Budgetary Medical Insitution Moscow Region Scietiic-Research Clinical Institute n.a. M.F. Vladimirsky, Moscow
Aim. Estimation of role of plasmapheresis in protection of renal transplant function.
Methods. 80 renal transplant recipients were included into the study. In 40 of the plasmapheresis was perfomed during 1st 24 hours of transplant repefusion; 40 patients did not undergo plasmapheresis. Immusupressive therapy was equal in both groups. Renal transplant function was estimated according to serum creatinine level, glomerular filtration rate (GFR), and hemodyalisis requirement after renal transplantation.
Results. Plasmapheresis, performed during 1st 24 hours after start of renal transplant reperfusion, lead to more prominent elevation of GFR and decrease in serum creatinine concentration. Number of patients, who required hemodyalisis after renal transplantation, was more than 5 times less in plasmapheresis group.
Conclusion. Plasmapheresis can be used for protection of renal transplant ischemia-reperfusion damage.

About the Autors

Vatazin A.V. – professor, head of transplantology, nephrology and surgery hemocorrection department, Advances Medical Education State Budgetary Medical Insitution Moscow Region Scietiic-Research Clinical Institute, Honored Scientist of Russian Federation, Ph.D.
Siniutin A.A. – head research associate of department of surgical donorship, Ph.D.;
Zul'karnaev A.B. – associate professor of transplantology, nephrology and artificial organs, Ph.D.
Kantaria R.O. – nephrologist of surgical department of transplantology and dialysis, Ph.D.
Krstich M. – junior scientific researcher at the department of surgical donorship, Ph.D.

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