Valganciclovir in cytomegalovirus prophylaxis in renal transplant recipients


E.I. Prokopenko, E.O. Shcherbakova, A.V. Vatazin, A.G. Yankovski, S.A. Pasov, V.A. Stepanov, D.V. Artemov

Faculty of Advances Medical Education State Budgetary Medical Insitution Moscow Region Scietiic-Research Clinical Institute n.a. M.F. Vladimirsky, Moscow
Aim. Estimation of efficacy of prophylaxis of cytomegalovirus infection with valganciclovir in renal transplant recipients.
Methods. Retrospective study included 349 renal transplant recipients: 171 of them received valganciclovir during 3 – 6 months. Patients, who received tacrolimus, more frequently used tacrolimus, those, who did not – cyclosporine. Median follow-up period duration was > 2 years (25,8 [12,5; 40,6] months in valganciclovir group, 65,4 [50,6; 97,4] months in control group). Results. Valganciclovir use lead to decrease of frequency of active cytomegalovirus infection during 12 months of follow-up (7,0 % vs 22,6 %, p < 0,001), frequency of replication of all herpes-group viruses (9,2 % vs 32,4 %, p < 0,001); trend to decrease of all pneumonias was also observed (9,7 % vs 16 %, p = 0,11). 1- and 2-year event-free survival was also higher in valganciclovir group (1-year: 78,4 % vs 65,2 %, p = 0,006; 2-year: 76,6 % vs 63,5 %, p = 0,009).
Conclusion. Use of valganciclovir in renal transplant recipients leads to decrease of frequency of active cytomegalovirus infection and increase in event-free survival.

About the Autors


Prokopenko E.I. – professor of transplantology, nephrology and surgery hemocorrection department at Faculty of Advances Medical Education State Budgetary Medical Insitution Moscow Region Scietiic-Research Clinical Institute n.a. M.F. Vladimirsky Ph.D.
e-mail: renalnephron@gmail.com;
Shcherbakova E.O. – assistant of transplantology, nephrology and surgery hemocorrection department at Faculty of Advances Medical Education State Budgetary Medical Insitution Moscow Region Scietiic-Research Clinical Institute n.a. M.F. Vladimirsky Ph.D.
Vatazin A.V. – professor, head of transplantology, nephrology and surgery hemocorrection department, Honored Scientist of Russian Federation, Ph.D.
Yankovoy A.G. – leading research associate at of transplantology, nephrology and surgery hemocorrection department, Ph.D.
Pasov S.A. – head of surgical department of transplantology and dialysis of State Budgetary Medical Insitution Moscow Region Scientific-Research Clinical Institute n.a. M.F. Vladimirsky, Ph.D.
Stepanov V.A. – head of organ donorship department at State Budgetary Medical Insitution Moscow Region Scientific-Research Clinical Institute n.a. M.F. Vladimirsky, Ph.D.
Artemov D.V. – clinical ordinator at the department of transplantology, nephrology and artificial organs at State Budgetary Medical Institution Moscow Region Scientific-Research Clinical Institute n.a. M.F. Vladimirsky.


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