Currently we have accumulated considerable experience of hydrochlorothiazide use in hypertensive patients justifying substantially decrease of risk of cardiovascular complications. The article discusses clinical studies confirming the advisability of hydrochlorothiazide use in patients with hypertension, as well as ways to prevent adverse events associated with its use, including type 2 diabetes mellitus.

Keywords: thiazides, hypokalemia, diabetes mellitus, arterial hypertension, hydrochlorothiazide