Efficacy of aggressive immunosuppressive therapy in patient with fulminant Shoenlein-Henoch purpura


S.V. Guliaev, A.D. Meshkov, P.I. Novikov, A.G. Semenovikh, N.V. Nikiforova, N.R. Nosova

Aim. Assessment of survival of children with steroid-resistant nephrotic syndrome in Ukraine, determination of risk factors for chronic renal failure development. Methods. Clinical evolution of 646 children with steroid-resistant nephrotic syndrome was performed according to the hospitalization periods (1980 - 2000 and 2001 - 2006). Results Clinical and morphological dynamics of steroid-resistant nephrotic syndrome in children was detected. In 1980 - 2000 the main risk factors for chronic renal failure development were renal function deterioration in the debut of the diasease and arterial hypertension. In 2001-2006 cumulative risk of chronic renal failure decreased (27,7% vs 39,7% in 1980-2000, p=0,008). In 2001-2006 risk of chronic heart failure became higher in boys aged 3-6 years. Conclusion. Dynamics of clinical and moprphological characteristics and chronic renal failure risk in children with chronic renal failure call for immunosuppressive therapy protocols optimization

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