Role of sulodexide in treatment of diabetic nephropathy in patients with type 1 diabetes mellitus


G.A. Alexandrovich, E.I. Andreeva, A.S. Markov, N.N. Morozova, G.A. Saneeva, I.A. Unanova

Endocrinology department of Post Diploma Education Faculty with
Aim. Determination of efficacy of sulodexide in diabetes mellitus (DM) type 1 patients with diabetic nephropathy (DN).
Methods. 108 patients (19 male, 17 female, age 24-27 years, mean duration of DM 7 – 16 years) were included into the study. 62 patients at baseline had microalbuminuria, 46 – proteinuria. The duration of treatment course with sulodexide was 4 weeks.
Results. Patients with microalbuminuria demonstrated significant decrease of albuminuria, in 50% of them – to normalbuminruia. In patients with baseline proteinuria changes of albuminuria were not significant.
Results. Sulodexide demonstrates antiproteinuric effect in DM patients with DN.

About the Autors


Alexandrovich G.A. – associate professor, Head of endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation, Ph.D.;
Tel . (8652) 75-24-64;
Andreeva, E.I., associate professor at endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation, Ph.D.;
Markova A.S. - endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation;
Morozova, G.A. – assistant of endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation;
Saneeva, I.A. - assistant of endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation, Ph.D.;
Unanova I.A. - endocrinology department, pediatric endocrinology and diabetology at Post Diploma Education Faculty State Budgetary Education Institution of High Professional Education Stavropol State Medical Academy Ministry of Health and Social Development of Russian Federation


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