Clinical assessment of circulating (pro-ANP) and renal interstitial (CGMP) natriuretic peptides in proteinuric forms of chronic glomerulonephritis


A.A. Pulin, T.Yu. Kustova, M.Yu. Brovko, L.V. Lysenko, V.V. Fomin, N.A. Muhin

MPF SBEI HPE First MSMU n.a. I.M. Sechenov of RMPH, Moscow
Aim. Detrmination of correlation of precursor of atrial natriuretic peptide (pro-ANP) and urinary excretion of circulating GMP (cGMP) and their relationship with activity of chronic glomerulonephritis (CGN).
Methods. 47 patients with CGN (28 male, 19 female, age 17–62 years) were divided into several groups: 1st (n=10) – with nephrotic syndrome and renal failure, 2nd (n=14) – with nephrotic syndrome without renal failure, 3rd – with non-nephrotic proteinuria, 4th – with hematuria, 9 healthy volunteers served as controls. In all patients plasma level of pro-ANP and urinary excretion of cGMP were determined.
Results. Urinary excretion of cGMP in healthy volunteers was higher, than in patients with CGN, in whom it’s level depended on the activity of renal damage. Patients with nephrotic syndrome had lowest levels of urinary cGMP, especially those with renal failure. Plasma pro-ANP level directly correlated with CGN activity.
Conclusion. Determination of plasma pro-ANP level and сGMP excretion can be used for determination of chronic glomerulonephritis activity and prognosis.

About the Autors


Pulin A.A., MD, PhD, associated professor of chair of internal, professional diseases and pulmonology of medico-prophylaxis faculty SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation; head of cryobank of FSBU SSC FMBC n.a. A.I. Burnazian of FMBA of Russia
andreypulin@gmail.com
Kustova T.E., research fellow of chair of of internal, professional diseases and pulmonology of medico-prophylaxis faculty SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Brovko M.Yu., research fellow of chair of of internal, professional diseases and pulmonology of medico-prophylaxis faculty SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Lysenko L.V., MD, PhD, professor of chair of of internal, professional diseases and pulmonology of medico-prophylaxis faculty SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
V.V. Fomin, MD, PhD, professor, professor of chair of internal, professional diseases and pulmonology of medico-prophylaxis faculty, vice-rector for medical affairs of SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Moukhin N.A., academician of RAS, MD, PhD, professor, head of chair of internal, professional diseases and pulmonology of medico-prophylaxis faculty, director of scientific clinical research center of health-preserving technologies SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation


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