Management of patients with thrombotic microangiopathy (TMA) is one of the problem areas in modern obstetrics and gynecology. The main types of TMA occuring during pregnancy and in the puerperium include preeclampsia, HELLP syndrome, thrombotic thrombocytopenic purpura (TTP), catastrophic antiphospholipid syndrome (CAPS), and atypical hemolytic uremic syndrome (aHUS). In most cases, preeclampsia is a precursor of the development of severe forms of TMA in pregnant women. The doctors' high concern about severe forms of TMA in patients with preeclampsia, timely differential diagnosis can prevent the development of catastrophic outcomes for the mother and child. The article presents a clinical case of the development of the aHUS in a 22-year old woman at late pregnancy with a description of approaches to differential diagnosis of TMA and treatment of aHUS.

Keywords: atypical HUS, microangiopathic hemolysis, Eculizumab, thrombocytopenia, preeclampsia, differential diagnosis, thrombotic microangiopathy