Русский
Impaired renal function in patients with degenerative distrophic diseases of the spine and axial spondyloarthritis receiving non-steroidal anti-inflammatory drugs
D.M. Bichurina, I.Z. Gaydukova, A.V. Aparkina, E.V. Khondkaryan, A.P. Rebrov
1 FSBEI HE Saratov State Medical University n.a. V.I. Razumovsky of RMH, Department of Hospital Therapy of the Medical Faculty; Saratov, Russia 2 FSBEI HE North-Wester State Medical University n.a. I.I. Mechnikov of RMH, Department of Therapy and Rheumatology; Saint-Petersburg, Russia
Materials and Methods. The study included 67 patients with chronic back pain of different genesis (44 patients with axial spondylarthritis (ax-SpA) and 23 patients with degenerative-dystrophic diseases of the spine (DDDS)) receiving NSAIDs in comparable dosages. Patients underwent assessment of glomerular filtration rate according to CKD-EPI and markers of renal damage (albuminuria and globulinuria, urine enzymes).
Results. In patients with ax-SpA, mean GFR was 95.0 [84.0; 102.0] ml/min/1.73 m2, in patients with DDDS, mean GFR was 77.5 [70.0; 89.0] ml/min/1.73 m2 (p=0.0003). The urine albumin level in patients with ax-SpA was 36.74 [25.06; 46.7] mg/g, in patients with DDDS – 73.08 [40.68; 120.76] mg/g (p=0.002); the α1-microglobulin level in patients with ax-SpA was 23.4 [18.24; 32.06] mg/g, in patients with DDDS – 161.66 [121.04; 225.78] mg/g, p=0.0000.
Conclusions. With a comparable total dose of NSAIDs taking for back pain, changes in glomerular and tubular renal function are more pronounced in patients with degenerative-dystrophic diseases of the spine than in patients with axial spondyloarthritis, which can be explained by the characteristics of NSAID intake in patients with different origin of back pain.
About the Autors
1. Bichurina D.M. – Postgraduate Student at the Department of Hospital Therapy of the Medical Faculty FSBEI HE SSMU n.a. V. I. Razumovsky of RMH; Saratov, Russia.
2. Gaydukova I.Z. – Doctor of medical Sciences, Associate Professor at the Department of Therapy and Rheumatology NWSMU n.a. I.I. Mechnikov of RMH; Saint-Petersburg, Russia.
3. Aparkina A.V. – Postgraduate Student at the Department of Hospital Therapy of the Medical Faculty FSBEI HE SSMU n.a. V. I. Razumovsky of RMH; Saratov, Russia.
4. Khondkaryan E.V. – Postgraduate Student at the Department of Hospital Therapy of the Medical Faculty FSBEI HE SSMU n.a. V. I. Razumovsky of RMH; Saratov, Russia.
5. Rebrov A.P. – Doctor of Medical Sciences, Professor, Head of the Department of Hospital Therapy of the Medical Faculty FSBEI HE SSMU n.a. V. I. Razumovsky of RMH; Saratov, Russia.
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