The meteoric rise of metabolic syndrome has made it a major global health problem. The results of studies show a higher frequency of kidney pathology in patients of this group. Abdominal obesity, hypertension, dyslipidemia, and insulin resistance are associated with effects on the kidneys through the systemic release of multiple pro-inflammatory cytokines, generalized oxidative stress, and the development of chronic inflammation. This review considers the main pathophysiological mechanisms of kidney damage and variants of their structural changes under the influence of each of the components of the metabolic syndrome. The most significant laboratory markers and possibilities of pharmacotherapy are discussed, the study of these parameters seems important in the timely prevention of chronic kidney disease in such patients.

Keywords: kidney damage, abdominal obesity, insulin resistance, metabolic syndrome, arterial hypertension, chronic kidney disease, dyslipidemia