Thrombotic microangiopathy in a patient with a genetic form of thrombofilia as a factor of the risk of progression of IgA-nephropathy


D.E. Rodriges, L.A. Bobrova, N.L. Kozlovskaya, E.S. Stolyarevich

1 FSAEI HE "First Moscow State Medical University n.a. I.M. Sechenov" of RMH; Moscow, Russia 2 Clinic of Nephrology, Internal and Occupational Diseases n.a. E.M. Tareev UCH № 3 3 SBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMH, Department of Internal, Occupational Diseases and Pulmonology; Moscow, Russia 4 SBHCI "City Clinical Hospital № 52" of Moscow Healthcare Department; Moscow, Russia
The article presents a clinical observation illustrating the possibility of a severe course of IgA-nephropathy when it combines with thrombotic microangiopathy (TMA). The reasons for the development of TMA are discussed. The features of this clinical observation also include malignant hypertension (MHT). The possible mechanisms of this unusual course of IgA-nephropathy, which is generally a benign disease, are discussed in the article
Keywords: multigene thrombophilia, malignant hypertension, hereditary thrombophilia, IgA-nephropathy, thrombotic microangiopathy, renal failure
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About the Autors

Rodriges D.E. – Postgraduate Student at the Department of Internal, Occupational Diseases and Pulmonology of the Public Health Faculty, FSAEI HE "First Moscow State Medical University n.a. I.M. Sechenov" of RMH; Moscow, Russia. E-mail: neicosha@yandex.ru
Bobrova L.A. – PhD in Medical Sciences, Senior Researcher at the Department of Nephrology, SRC FSAEI HE "First Moscow State Medical University n.a. I.M. Sechenov" of RMH; Moscow, Russia.
Kozlovskaya N.L. – Doctor of Medical Sciences, Professor at the Department of Internal, Occupational Diseases and Pulmonology of the Public Health Faculty, FSAEI HE "First Moscow State Medical University n.a. I.M. Sechenov" of RMH; Moscow, Russia.
Stolyarevich E.S. – Doctor at the Pathoanatomical Department of the SBHCI "City Clinical Hospital № 52" of Moscow Healthcare Department, Professor at the Department of Nephrology FAPE FSBEI HE "MSMSU n.a. A.I. Evdokimov"


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