Русский
The beneficial effect of fish oil on the idiopathic hypercalciuria in children
DOI: https://dx.doi.org/10.18565/nephrology.2018.2.64-67
N.M. Mikheeva, Ya.F. Zverev, G.I. Vykhodtseva, Yu.F. Lobanov
FSBEI HE "Altai State Medical University" of RMH; Barnaul, Russia
Objective. Evaluation of the effectiveness of the use of fish oil preparations in children with hypercalciuria.
Material and Methods. The study included 27 children aged 3 to 10 years (mean age 6.0±2.23 years) with detected hypercalciuria according to the calcium-creatinine coefficient in urine above 0.6 mmol/mmol, with normal plasma calcium and parathyroid hormone levels. Genealogical history was analyzed; somatic status assessment, general clinical and biochemical studies of blood and urine samples with determination of the content of calcium and creatinine in the urine to calculate the calcium-creatinine coefficient. To assess the state of the organs of the urinary system, instrumental methods of diagnosis were used.
Results. Anomalies in the development of the urinary system were revealed in 62.9% of children with hypercalciuria; 22.2% of patients had a urinary tract infection, and 18.5% had neurogenic urination disorders. More than half (59.3%) of children with hypercalciuria had burdened familial history of urolithiasis. Clinically, in the children examined dysuric (48.1%) and painful (18.5%) syndromes were identified. Oxaluria was registered in the urinary sediment in 29.6% of the children, and microhematuria in 18.5%. 48.1% of patients suffered hyperstenuria. All children with hypercalciuria prescribed fish oil at a daily dose of 1000 mg for preschool children and 1500 mg for schoolchildren. The course of therapy was 3 months. Evaluation of clinical and laboratory manifestations after 3 months of therapy showed a significant increase in the daily volume of urine in a number of children, which was accompanied by a decrease in its specific weight. Red blood cells were not detected in the field of vision in urine tests in 60% of children with previous hematuria after 3 months. The calcium-creatinine coefficient was normalized in 14 (51.9%) patients.
Conclusion. The use of fish oil preparations for 3 months at a dose of 1000-1500 mg contributes to the disappearance of symptoms of idiopathic hypercalciuria and the normalization of urine calcium excretion in more than 50% of children.
Material and Methods. The study included 27 children aged 3 to 10 years (mean age 6.0±2.23 years) with detected hypercalciuria according to the calcium-creatinine coefficient in urine above 0.6 mmol/mmol, with normal plasma calcium and parathyroid hormone levels. Genealogical history was analyzed; somatic status assessment, general clinical and biochemical studies of blood and urine samples with determination of the content of calcium and creatinine in the urine to calculate the calcium-creatinine coefficient. To assess the state of the organs of the urinary system, instrumental methods of diagnosis were used.
Results. Anomalies in the development of the urinary system were revealed in 62.9% of children with hypercalciuria; 22.2% of patients had a urinary tract infection, and 18.5% had neurogenic urination disorders. More than half (59.3%) of children with hypercalciuria had burdened familial history of urolithiasis. Clinically, in the children examined dysuric (48.1%) and painful (18.5%) syndromes were identified. Oxaluria was registered in the urinary sediment in 29.6% of the children, and microhematuria in 18.5%. 48.1% of patients suffered hyperstenuria. All children with hypercalciuria prescribed fish oil at a daily dose of 1000 mg for preschool children and 1500 mg for schoolchildren. The course of therapy was 3 months. Evaluation of clinical and laboratory manifestations after 3 months of therapy showed a significant increase in the daily volume of urine in a number of children, which was accompanied by a decrease in its specific weight. Red blood cells were not detected in the field of vision in urine tests in 60% of children with previous hematuria after 3 months. The calcium-creatinine coefficient was normalized in 14 (51.9%) patients.
Conclusion. The use of fish oil preparations for 3 months at a dose of 1000-1500 mg contributes to the disappearance of symptoms of idiopathic hypercalciuria and the normalization of urine calcium excretion in more than 50% of children.
Keywords: fish oil, idiopathic hypercalciuria
About the Autors
Mikheeva N.M. – PhD in Medical Sciences, Associate Professor at the Department of Propaedeutics of Children's Diseases FSBEI HE ASMU of RMH; Barnaul, Russia.
E-mail: micheeva.1974@mail.ru
Zverev Ya.F. – Doctor of Medical Sciences, Professor at the Department of Pharmacology FSBEI HE ASMU of RMH; Barnaul, Russia.
Vykhodtseva G.I. – Doctor of Medical Sciences, Professor, Head of the Department of Pediatrics with the Course of FPE FSBEI HE ASMU of RMH; Barnaul, Russia.
Lobanov Yu.F. – Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Children's Diseases FSBEI HE ASMU of RMH; Barnaul, Russia.
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