Persistent hematuria as frequent manifestation of idiopathic hypercalciuria in children


N.M. Mikheeva, Ya.F. Zverev, G.I. Vykhodtseva, Yu.F. Lobanov.

SBEI HPE Altai State Medical University of the RMPH, Barnaul
Aim. Identification of idiopathic hypercalciuria in children with persistent hematuria (PH).
Material and methods. The study included 65 children aged 1 month to 15 years (mean age 6,5±1,3 years) with PH diagnosed during the period 2012 to 2014. The evaluation of genealogical history, assessment of physical status, clinical and biochemical blood and urine tests to determine the serum and urine calcium, phosphorus, urea, and creatinine levels were performed. Calcium/creatinine ratio was calculated. Instrumental methods were used for the assessment of the state of the urinary system.
Results. 50.8% of children with PH had experienced infection of the urinary system, 23.1% of patients had abnormal development of the urinary system, and 21.5% had urolithiasis. More than half (56.9%) children with hematuria had burdened familial history of urolithiasis. Clinically, children with PH often had dysuric (44.6%) and pain (24.6%) syndromes. In the urinary sediment, crystalluria, with significantly more frequent oxaluria, was observed in 33.8% of children with hematuria. Idiopathic hypercalciuria was detected in 27 (41.5%) children with PH.
Conclusion. Identification of idiopathic hypercalciuria in 41.5% of children with PH suggests a presence of relationship between these pathological manifestations.

About the Autors


Information about the authors:
Mikheeva NM – PhD in Medical Sciences, Associate Professor at the Department of Pediatrics № 2 SBEI HPE ASMU of RMPH. E-mail: micheeva.1974@mail.ru
Zverev Ya.F. – MD, Professor at the Department of Pharmacology SBEI HPE ASMU of RMPH
Vykhodtseva G.I. – MD, Head of the Department of Pediatrics № 1 SBEI HPE ASMU of RMPH
Lobanov Yu.F. – MD, Head of the Department of Pediatrics № 2 SBEI HPE ASMU of RMPH


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