Membranose glomerulonephritis in the practice of a therapist


DOI: https://dx.doi.org/10.18565/nephrology.2021.3.66-77

I.T. Murkamilov, I.S. Sabirov, V.V. Fomin, Zh.A. Murkamilova, I.O. Kudaibergenova, F.A. Yusupov

1) I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan; 2) Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan; 3) Sechenov University, Moscow, Russia; 4) Osh State University, Osh, Kyrgyzstan
Membranous glomerulonephritis (MGN) is characterized by diffuse thickening and changes in the structure of the basement membrane of the glomeruli due to subepithelial and intramembranous deposition of immune complexes and the deposition of matrix material produced by affected podocytes. As the most common cause of nephrotic syndrome in adults, MGN is divided into primary (idiopathic) and secondary forms. The primary task of examining a patient with newly diagnosed MGN is to exclude secondary causes of the disease. Primary MGN develops more often in young and middle-aged people. Secondary MGN is more common in children. In MGN, it is necessary to test for the A2 phospholipase receptor (PLA2R1) antigen, anti-PLA2R1 IgG antibodies and determine the number of cells in the glomerular infiltrate. Persons of older age groups in the absence of deposits with anti-PLA2R1 antibodies and in the presence of IgG2 and IgG1 deposits need additional examination for the presence of a paraneoplastic process.
Keywords: thrombospondin-1, autoimmune inflammation, secondary membranous glomerulonephritis, PLA2R, membranous glomerulonephritis
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About the Autors

Ilkhom T. Murkamilov – Cand. Sci. (Med.), Deputy Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev Kyrgyz State Medical Academy;
Senior Lecturer at the Department of Therapy № 2 in the specialty "General Medicine”, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan.
E-mail: murkamilov.i@mail.ru, ORCID: org/0000-0001-8513-9279.
Ibragim S. Sabirov – Dr. Sci. (Med.)., Professor, Head of the Department of Therapy № 2 in the specialty "General Medicine", Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan; e-mail: sabirov_is@mail.ru; ORCID: org / 0000-0002-8387-5800.
Viktor V. Fomin – Dr. Sci. (Med.)., Professor, Corresponding Member of RAS, Head of the Department of Faculty Therapy № 1, N.F. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Clinical Work and Postgraduate Professional Education, Sechenov University; Moscow, Russia. E-mail: fomin_vic@mail.ru, ORCID: org / 0000-0002-2682-4417.
Zhamila A. Murkamilova – Correspondence Post-Graduate Student at the Department of Therapy № 2 in the specialty "General Medicine", Kyrgyz-Russian Slavic University, Bishkek; e-mail: murkamilovazh.t@mail.ru ORCID: org / 0000-0002-7653-0433.
Indira O. Kudaibergenova – Dr. Sci. (Med.), Professor, Rector of the I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan; e-mail: k_i_o2403@mail.ru;
ORCID: org / 0000-0003-3007-8127.
Furkat A. Yusupov – Dr. Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University,
Chief Neurologist of the Southern Region of Kyrgyzstan; Osh, Kyrgyzstan; e-mail: furcat_y@mail.ru; ORCID: org / 0000-0003-0632-6653.


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