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Effect of VEGF a on the development of tubulointerstitial fibrosis and the probability of achieving complete remission in patients with primary chronic glomerulonephriti
DOI: https://dx.doi.org/10.18565/nephrology.2021.4.48-52
A.V. Mukhtarova, M.M. Batyushin, E.А. Sinelnik, N.V. Antipova, A.V. Razina
1) Department of Internal Medicine № 2, Rostov State Medical University, Rostov-on-Don, Russia; 2) Nephrology Department, Clinic of the Rostov State Medical University, Rostov-on-Don, Russia; 3) Department of Morbid Anatomy, Regional Clinical Hospital № 2, Rostov-on-Don, Russia; 4) Nephrology Department, Regional Clinical Hospital № 2, Rostov-on-Don, Russia
Material and methods. The study included 75 patients aged 18 to 75 years. All participants underwent clinical and laboratory examination, kidney needle biopsy with staining of biopsy samples with a specific labeled antibody to VEGF A to determine its expression in kidney tissue.
Results. The maximum VEGF A expression was observed in the initial collecting tubules in all 75 biopsy samples. A direct association was found between the VEGF A expression and the severity of TIF (r – 0.26; P<0.05). Logistic regression analysis demonstrated the probability of achieving remission with a minimum VEGF A expression equal to 34%, which is by 22% greater than with pronounced expression.
Conclusion. Dysregulation of VEGF A expression in the kidney tissue leads to the development of TIF and a decrease in the probability of reaching the complete remission in patients with primary chronic glomerulonephritis.
About the Autors
Aytan V. Mukhtarova – Head of the Dialysis Department № 2, OOO DC NEPHROS-DON, Cand. Sci. (Med.) degree seeker at the Department of Internal Medicine № 2, Rostov State Medical University, Rostov-on-Don, Russia; e-mail: ayka.mukhtarova@gmail.com. ORCID: 0000-0001-6367-6727
Mikhail M. Batyushin – Dr. Sci. (Med.), Professor, Professor at the Department of Internal Medicine № 2, Head of the Nephrology Department of the Clinic of the Rostov State Medical University, Rostov-on-Don, Russia; e-mail: batjushin-m@rambler.ru. ORCID: 0000-0002-2733-4524
Elena A. Sinelnik – Cand.Sci. (Med.), Head of the Department of Morbid Anatomy, Regional Clinical Hospital № 2, Rostov-on-Don, Russia; e-mail: ob2p@mail.ru
Natalya V. Antipova – Head of the Nephrology Department, Regional Clinical Hospital № 2, Rostov-on-Don, Russia; e-mail: ob2p@mail.ru
Aleksandra V. Razina – Cand.Sci. (Med.), Nephrologist at the Nephrology Department of the Clinic of the Rostov State Medical University, Rostov-on-Don, Russia;
e-mail: pasechnik-alexandra@mail.ru
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