The relevance of research in the development of methods for non-invasive laboratory diagnostics of chronic kidney disease and concomitant chronic renal failure is due to the high frequency of their occurrence, long-term asymptomatic course of the disease and the high cost of treatment for this category of patients: the cost of their treatment makes up a significant part of the national health budgets of developed countries with a comparatively small proportion of these patients from the total number of all patients.
The aim of this work was to assess the capabilities of saliva spectroscopy by the method of monochrome analysis of nanoparticles to study the characteristic features of its subfractional composition in patients with chronic kidney disease with the development of chronic renal failure. To do this, it is necessary to solve a number of problems: to develop a diagnostic algorithm for monochrome analysis of nanoparticles to determine the severity and pathophysiological orientation of homeostatic changes in patients with various forms of chronic kidney disease using samples from oropharyngeal swabs.
Material and methods. Studies were carried out at the Center for European and Oriental Medicine from 2019 to 2021 (39 patients with verified diagnoses of chronic kidney disease were examined), during which it was found that the most typical saliva spectra of these patients were characterized by a multimodal distribution of nanoparticles saliva in size and contribution to light scattering on large particles larger than 1000 nm, which was statistically significant (p <0.001) when conducting a comparative analysis with saliva spectra of practically healthy individuals and patients with general somatic inflammatory kidney diseases without the development of chronic renal failure. The indicator of the diagnostic sensitivity of the method in relation to chronic kidney disease with chronic renal failure was 92%.
Conclusions. The use of laser spectroscopy of saliva is scientifically substantiated for the non-invasive detection of chronic kidney diseases with the development of chronic renal failure, when, with a timely diagnosis, therapeutic measures will be most effective.

Keywords: non-invasive diagnosis of chronic renal failure, monochrome nanoparticle analysis, saliva, chronic renal failure, chronic kidney disease