Modern strategies for the treatment of patients with autosomal dominant polycystic kidney disease


DOI: https://dx.doi.org/10.18565/nephrology.2022.4.33-42

Trushkin R.N., Medvedev P.E., Isaev T.K., Klementieva T.M., Morozov N.V., Ivanov K.V.

1) City Clinical Hospital № 52 of the Moscow Healthcare Department, Moscow, Russia; 2) Moscow Multidisciplinary Clinical Center "Kommunarka" of the Moscow Healthcare Department, Moscow, Russia
According to WHO data for 2019, kidney disease ranks 10th in the structure of the leading causes of death in the world with a total number of deaths of 1.3 million people. Based on large cohort studies, the global prevalence of chronic kidney disease (CKD) in the general population, averaged 13.4%. Autosomal dominant polycystic kidney disease (ADPKD) deserves special attention; it is characterized by the formation of cysts, a progressive increase in the volume of the kidneys with destruction of the parenchyma, a decrease in the glomerular filtration rate, and the occurrence of various complications. Recently, new targeted therapeutic drugs have appeared, their action is based on the pathogenetic mechanisms of ADPKD progression. The article presents a literature review of various methods in the treatment (conservative and surgical) of ADPKD.
Keywords: tolvaptan, renal replacement therapy, infection of kidney cysts, autosomal dominant polycystic kidney disease, nephrectomy, chronic kidney disease
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About the Autors

Ruslan N. Trushkin – Dr.Sci. (Med.), Head of the Department of Urology, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. e-mail: uro52@mail.ru. ORCID: https://orcid.org/0000-0002-3108-0539.
Pavel E. Medvedev – Urologist, Urology Department, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. e-mail: pah95@mail.ru. ORCID: https://orcid.org/0000-0003-4250-0815
Teymur K. Isaev – Cand. Sci. (Med.), Urologist, Urology Department, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. e-mail: dr.isaev@mail.ru, ORCID: https://orcid.org/ 0000-0003-3462-8616
Tamara M. Klementieva – Nephrologist, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; tel.: +7 (915) 473-23-09; e-mail: tamara-Klementeva@mail.ru.
Nikolay V. Morozov – Urologist, Urology Department, City Clinical Hospital № 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182: tel.: +7 (903) 686-14-18; e-mail: nikmorozov@rambler.ru.
ORCID: https://orcid.org/0000-0002-4256-6083
Konstantin V. Ivanov – Urologist, Urology Department, Moscow Multidisciplinary Clinical Center "Kommunarka" of the Moscow Healthcare Department. Address: Bldg.4, 8 Sosensky Stan st., Kommunarka settlement., Moscow, 129301


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