Background. Secondary hyperparathyroidism (SHPT) is the most common type of mineral-bone disorder (MBD), closely associated not only with an increased risk of progression of chronic kidney disease (CKD), but also with damage to the cardiovascular system (CVS).
Objective. Evaluation of the clinical and laboratory features of SHPT against the background of CKD in Tyumen region.
Material and methods. A retrospective analysis of 416 medical records of patients with diagnoses of CKD stage 3–5 and SHPT who were examined and treated in the Nephrology Department of Tyumen Regional Clinical Hospital No. 1 during the period from 01/01/2018 to 12/31/2022 was carried out. Demographic and anthropometric data were studied, laboratory (total and ionized calcium, total protein, albumin, phosphorus, creatinine, parathyroid hormone, 25(OH)D, alkaline phosphatase) tests and and instrumental methods of diagnosis (Echo-CG, ultrasound of the abdominal cavity and retroperitoneal space) were assessed.
Results. There were 184 (44.2%) men and 232 (55.8%) women. The mean age of the study subjects was 56.7±14.02 years. The mean duration of CKD was 3.5±4.3 years. According to the etiological structure of CKD among all patients, the leading position was occupied by primary kidney diseases (60%), including: polycystic kidney disease – 21%, chronic glomerulonephritis – 14%, chronic pyelonephritis – 19%, chronic tubulointerstitial nephritis – 6%. The second place in the etiological structure of CKD was occupied by diabetes mellitus (27%) and 13% by other diseases. Analysis of laboratory parameters of the examined patients confirmed the presence of the classic course of SHTP in patients with CKD: an increase in the mean parathyroid hormone level by 5.3 times, serum creatinine – by 6.5 times, as well as a slight increase in phosphorus and alkaline phosphatase levels compared with reference values were detected.

Keywords: 25(OH)D, parathyroid hormone, secondary hyperparathyroidism, cardiovascular diseases, chronic kidney disease