The choice of the method of anticoagulation during various extracorporeal procedures is relevant in view of the increasing frequency of the use of this procedure by doctors of various specialties. Regional citrate anticoagulation (RCA) has a number of advantages over systemic anticoagulation with heparin, including: longer filter life in renal replacement therapy (RRT), lower risk of bleeding. In order to achieve maximum efficiency and safety of RCA, many different citrate dosing algorithms have been proposed; protocol citrate anticoagulation with 4% sodium citrate is the most studied. This literature review discusses the main studies evaluating the efficacy and safety of this technique. Currently, research results allow professional communities to recommend CAR as the method of choice for extended RRT.

Keywords: extracorporeal hemocorrection, regional citrate anticoagulation, sodium citrate, renal replacement therapy