Castleman's disease associated with amyloidosis. Literature review and clinical observation


DOI: https://dx.doi.org/10.18565/nephrology.2023.2.62-73

Frolova N.F., Varyasin V.V., Volgina G.V., Sysoeva I.L., Mudarisov R.R., Usatyuk S.S., Dyakova E.N., Stolyarevich E.S.

1) City Clinical Hospital № 52 of the Moscow Healthcare Department, Moscow, Russia; 2) A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
A brief review of the literature on Castleman's disease (CD), a rare heterogeneous group of lymphoproliferative diseases of unknown etiology with characteristic lymph node histopathology, is presented. Depending on the clinical, pathological, virological features and course, the modern classification of CD includes a unicentric variant (UCD) with a localized lesion of a single lymph node, a generalized or multicentric variant (MCD) with lymphadenopathy in several nodes, and an intermediate variant – oligocentric, or regional, affecting lymph nodes in two – three neighboring areas. Differential diagnosis of CD requires mandatory testing for infection with the herpes virus (HHV8) and human immunodeficiency virus, as well as the exclusion of all concomitant diseases, since CD can be accompanied by the development of Hodgkin's lymphoma and non-Hodgkin's lymphomas, Kaposi's sarcoma, which has important prognostic and therapeutic value. Amyloidosis AA (AA-A) is caused by a wide range of inflammatory conditions but is rarely associated with CD.
Description of the clinical case. We report a clinical case of a 29-year-old woman with idiopathic multicentric plasma cell variant of CD, complicated by AA amyloidosis with kidney and lymph node damage, restrictive cardiomyopathy, and dialysis-requiring end-stage renal failure.
Keywords: AA amyloidosis, multicentric, unicentric, Castleman's disease, lymphoproliferative diseases
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About the Autors

Nadiya F. Frolova – Cand. Sci. (Med.), Deputy Chief Physician for Nephrological Care, City Clinical Hospital №52 of the Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182. A.I. Yevdokimov Moscow State University of Medicine and Dentistry. Address: Bldg. 1, 20 Delegatskaya st., Moscow, 127473.
E-mail: nadiya.frolova@yandex.ru. ORCID: https://orcid.org/0000-0003-3234-8266
Valery V. Varyasin – Cand.Sci. (Med.), Head of the Pathological Anatomical Department, City Clinical Hospital №52 of the Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: pao52@mail.ru. ORCID: https://orcid.org/0000-0003-1136-6203
Galina V. Volgina – Dr. Sci. (Med.), Professor, A.I. Yevdokimov Moscow State University of Medicine and Dentistry. Address: Bldg. 1, 20 Delegatskaya st., Moscow, 127473. E-mail: volginagv@mail.ru. ORCID: https://orcid.org/0000-0002-7771-4074
Irina L. Sysoeva – Doctor at the Nephrology Department, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: i.l.sysoeva@mail.ru ORCID: https://orcid.org/0000-0002-1904-9846
Rinat R. Mudarisov – Cand. Sci. (Med.), Deputy Chief Physician for Surgical Care, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: docmr@rambler.ru. ORCID: https://orcid.org/0000-0001-8890-4669
Sergey S. Usatyuk – Head of the Nephrology Department, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: usatuk-doc@mail.ru. ORCID: https://orcid.org/0000-0002-8742-3860
Ekaterina N. Dyakova – Doctor at the Nephrology Department, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: katerina-diakova@mail.ru. ORCID: https://orcid.org/0000-0003-1599-1639
Ekaterina S. Stolyarevich – Dr. Sci. (Med.), Professor at the Department of Nephrology, FAPE, A.I. Yevdokimov Moscow State University of Medicine and Dentistry.
Address: Bldg. 1, 20 Delegatskaya st., Moscow, 127473. Pathologist at the Department of Pathological Anatomy, City Clinical Hospital №52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182. E-mail: Stolyarevich@yandex.ru. ORCID: https://orcid.org/0000-0002-0402-8348

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