Objective. Evaluation of the possible influence of genetic markers of thrombogenic risk on hemostasis in patients on program hemodialysis
Material and methods. The frequency of detection of polymorphism in 12 genes of the hemostasis system was determined in 70 dialysis patients.
Results. Polymorphism of various genes was found in all patients. The most frequently detected polymorphism was the 5G(675)4G polymorphism of the PAI-1 gene. A high frequency of polymorphism of folate cycle genes was revealed. In patients with thrombosis, the frequency of polymorphism of the platelet receptor β-3 fibrinogen gene ITGB3 1565 T>C (Leu33Pro) was significantly higher than in patients without thrombosis (40% versus 14.3%; P = 0.016). Polymorphism of this gene was identified as a factor associated with the development of thrombosis in dialysis patients (OR=4.0, 95% CI 1.25–12.8). In patients with thrombosis, a combination of polymorphism of the PAI-1 gene, platelet factor genes ITGB3 and ITGA2 and folate cycle genes MTHFR: 1298 A>C and MTHFR: 677 C>T was significantly more often determined. The combination of polymorphisms of these genes was also associated with the development of thrombosis in dialysis patients.
Conclusion. Dialysis patients may have a genetic predisposition to the development of thrombotic complications. A genetic factor associated with a high risk of thrombosis was the 1565 T>C (Leu33Pro) polymorphism of the platelet receptor β-3 fibrinogen gene ITGB3, as well as a combination of polymorphisms of the PAI-1 gene, platelet factor genes and the folate cycle.

Keywords: polymorphism of thrombophilia genes, chronic kiney disease, program hemodialysis, thrombosis