Relationship of hyperchemerinemia and parameters of nutritive status in patients with chronic renal insufficiency

V.N. Poganeva, M.M. Batyushin, L.I. Efimenko

The aim of the study was to reveal the relationship between the serum chemerin levels and certain parameters that reflect the development of disorders of nutritional status.
Patients and methods: The study included 83 patients from two ambulatory hemodialysis centers. All patients underwent anamnestic, anthropometric, and laboratory examination; the results of additional methods of diagnosis were analyzed, including carpal dynamometry and other physical examination data; also, serum chemerin levels were assessed.
Results. As a result of the study, the following data were obtained: significantly elevated chemerin levels were detected in all subjects absolutely (its concentration was 450.1 ng/ml), while the level of this indicator was on the average within 524.68±82.45 ng/ml in women, and 392.67±80.34 ng/ml in men, it was higher than the normal indices of healthy people. During the study, a positive correlation between the subcutaneous fat thickness over the abdomen and the serum chemerin level was found (r=0.49, p<0.012), and a relationship between the plasma chemerin level and the dry weight of the patient (r=-0.3; p<0.014) was established. Data have been obtained indicating a negative correlation of capral dynamometry (r=-0.44, p<0.001) with serum chemerin level and serum creatinine level (r=-0.473, p<0.005). As a result of the study, a positive correlation between the serum chemerin level and the duration of the disease was found (r=0.61, p<0.001).
Conclusion. Thus, data on the role of chemerin in metabolic processes and nutritional status parameters in patients with ESRF receiving RRT by PHD were obtained.

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