Biological significance of differentially expressed genes of hypoxic-ischemic acute kidney injury (part 2)


DOI: https://dx.doi.org/10.18565/nephrology.2024.4.53-72

Popov S.V., Guseinov R.G., Yesayan A.M., Isakova-Sivak I.N., Sivak K.V., Skryabin O.N., Gorbacheva I.A., Matveeva D.A., Grushevsky R.O., Kovalevskaya A.V., Beshtoev A.Kh., Malyshev E.A., Lelyavina T.A.

1) St. Luke's Clinical Hospital, St. Petersburg, Russia; 2) S.M. Kirov Military Medical Academy, St. Petersburg, Russia; 3) St. Petersburg State University, St. Petersburg, Russia; 4) A.A. Smorodintsev Research Institute of Influenza, St. Petersburg, Russia; 5) St. Petersburg Medical and Social Institute, St. Petersburg, Russia; 6) V.A. Almazov National Medical Research Center, St. Petersburg, Russia
The study of the mechanisms of cell death is currently one of the most rapidly developing areas of modern biomedicine. Acute kidney injury is characterized by massive cell death and subsequent marked decline in kidney function. The review presents data on the molecular mechanisms of proximal renal tubule cell death in acute kidney injury. This information will provide characterization of the etiology and pathogenesis of the disease at the molecular level, and also serve as a basis
for searching for targets for effective renoprotective therapy in many pathological processes in the kidneys.

About the Autors


Sergey V. Popov – Dr.Sci. (Med.), Professor, Chief Physician of the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044, S.M. Kirov Military Medical Academy. Address: 194044, St. Petersburg; e-mail: lucaclinic.ru. ORCID: https://orcid.org/0000-0003-2767-7153.
Ruslan G.Guseynov – Cand.Sci. (Med.), Deputy Chief Physician for Research, St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; e-mail: lucaclinic.ru. ORCID: https://orcid.org/0000-0001-9935-0243.
Ashot M. Yesayan – Dr.Sci. (Med.), Professor, Head of the Department of Nephrology and Dialysis, Pavlov University, Chief Nephrologist of the Northwestern Federal District of the Russian Federation. Address: 17 L.Tolstoy st., St. Petersburg, 197022; e-mail: essaian.ashot@gmail.com. ORCID: 0000-0002-7202-3151.
Irina N. Isakova-Sivak – Dr.Sci. (Biol.), Corresponding Member of the Russian Academy of Sciences, St. Luke's Clinical Hospital, Research Department, Leading Researcher. Address: 46 Chugunnaya St., St. Petersburg, 194044. e-mail: isakova.sivak@iemspb.ru. ORCID: 0000-0002-2801-1508.
Konstantin V. Sivak – Dr.Sci. (Biol.), Head of the Laboratory of Drug Safety, A.A. Smorodintsev Research Institute of Influenza. Address: 197022, St. Petersburg; e-mail: kvsivak@gmail.com. ORCID: https://orcid.org/0000-0003-4064-5033
Oleg N. Skryabin – Dr.Sci. (Med.), Professor; Chief Oncologist, St. Luke's Clinical Hospital, Scientific Director of the Center for Endoscopic Urology and New Technologies. Address: 46 Chugunnaya St., St. Petersburg, 194044.; Tel.: +7 (812) 576-11-08; e-mail: skryabin_55@mail.com. ORCID: 0000-0002-6664-2861.
Irina A. Gorbacheva – Dr.Sci. (Med.), Professor, Chief Therapist of the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044;
e-mail: kvbsf@yandex.ru. ORCID: 0000-0002-9044-7257.
Darya A. Matveeva – Head of the Nephrology Department, Nephrologist of the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; e-mail: matveeva.darya.1990@mail.ru. ORCID: 0 009-0006-2878-657X.
Anastasia V. Kovalevskaya – Nephrologist of the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; e-mail: stenia1407@mail.ru. ORCID: 0009-0004-9544-7944.
Roman O. Grushevsky – Urologist, Oncologist of the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: flametah@yandex.ru. ORCID: 0009-0006-9032-7729.
Akhmed Kh. Beshtoev – Researcher at the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: akhmed.beshtoev@gmail.com. ORCID: 0009-0004-9544-7944.
Egor A. Malyshev – Researcher at the St. Luke's Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: malyshevyegor@gmail.com. ORCID: 0000-0001-6294-6182.
Tatyana A. Lelyavina – Dr.Sci. (Med.), Leading Researcher, Almazov National Medical Research Center. Address: Saint Petersburg;
e-mail: tatianalelyavina@mail.ru. ORCID: https://orcid.org/0000-0002-1834-4982.


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