Acute tubulointerstitial nephritis of medicinal etiology: the focus is on antibacterial drugs


DOI: https://dx.doi.org/10.18565/nephrology.2023.3.61-68

Murkamilov I.T., Fomin V.V., Sabirov I.S., Yusupov F.A., Satkynalieva Z.T.

1 I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan 2 SEI HPE Kyrgyz-Russian Slavic University named after the first President of the Russian Federation B.N. Yeltsin, Bishkek, Kyrgyzstan 3 FSAEI HE First Moscow State Medical University named after I.M. Sechenov (Sechenov University), Moscow, Russia 4 Osh State University, Osh, Kyrgyzstan
Summary. The urgency of the problem of acute tubulo-interstitial nephritis (TIN) in the clinic of internal diseases continues to grow. The widespread and uncontrolled use of drugs, in particular antibiotics, is accompanied by a high risk of developing acute TIN, since the high metabolic load and relatively lower blood supply make the tubulointerstations of the renal tissue very vulnerable. Due to the lack of widespread renal biopsy in the CIS countries, including the Kyrgyz Republic, the prevalence and incidence of acute TIN is underestimated. The article provides data on the nephrotoxicity of a number of antibacterial drugs, which are especially popular among doctors in the CIS countries. The diagnostic value of renal biopsy in the verification of acute TIN with a progressive decline in renal function has been shown. The article presents the results of studies that have shown the therapeutic efficacy and safety of the steroids in the treatment of acute TIN. The review article presents scientific data on clinical cases of acute TIN associated with antibiotics, including their combined use. Early recognition and appropriate treatment of antibiotic-associated TIN will ultimately reduce the likelihood of developing chronic kidney disease. The data of the review article emphasize the need for a personalized approach when prescribing antibiotics, especially in the presence of comorbid situations, including in elderly and senile people.
Keywords: tubulointerstitial nephritis, antibiotics, acute kidney injury, inflammation, risk factors
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About the Autors

Murkamilov Ilkhom T. – Dr. Sci. (Med.), Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev KSMA, Associate Professor at the Department of Therapy No.2, KRSU named after B.N. Yeltsin. Address: Kyrgyzstan, 72002092 Bishkek, Akhunbaev str.; e-mail: murkamilov.i@mail.ru. ORCID: org/0000-0001-8513-9279.
Fomin Viktor V. – Corresponding Member of RAS, Dr. Sci. (Med.), Professor, Head of the Department of Faculty Therapy No1, N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities, Sechenov University. Address: 1199912 Moscow, Bolshaya Pirogovskaya str.; e-mail: fomin_vic@mail.ru. ORCID: org/0000- 0002-2682-4417.
Sabirov Ibragim S. – Dr.Sci. (Med.), Professor, Head of the Department of Therapy No. 2 of the Medical Faculty, KRSU named after B.N. Yeltsin. Address: Kyrgyzstan, 72002244 Bishkek, Kiev str.; e-mail: sabirov_is@mail.ru. ORCID: org/0000-0002-8387-5800.
Yusupov Furkat A. – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry of the Medical Faculty, Osh State University, Chief Neurologist of the Southern Region of Kyrgyzstan. Address: Kyrgyzstan, 714000 Osh, 331 Lenin str.; e-mail: furcat_y@mail.ru. ORCID: org/0000-0003-0632-6653.
Satkynalieva Zina T. – Cand. Sci. (Med.), Associate Professor of the Department of Faculty Therapy of the I.K. Akhunbayev KSMA, Address: Kyrgyzstan, 720020 Bishkek, 92 Akhunbayev str. ORCID: org/0000-0002-1019-8562.


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