Русский
Predictors of fatal outcome in patients hospitalized for renal pyelonephritis
DOI: https://dx.doi.org/10.18565/nephrology.2025.1.37-46
Andreev S.S., Trushkin R.N., Isaev T.K., Artyukhina L.Yu., Frolova N.F., Ilyukhina N.N., Narusova P.O., Abdullaev Sh.P., Dushkin A.D., Lysenko M.A., Zhuravleva M.V.
1) City Clinical Hospital No. 52 of Moscow Healthcare Department, Moscow, Russia; 2) Pirogov RNRMU (Pirogov University), Moscow, Russia; 3) Scientific Center for Expertise of Medical Products, Moscow, Russia; 4) Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Material and methods. A single-center retrospective study was conducted, which included 501 patients with GP. Demographic, clinical, laboratory and instrumental data, as well as outcomes, were assessed. Logistic regression was used to identify predictors of mortality.
Results. Overall mortality in the study cohort was 5.19% (26 cases). Statistically significant predictors of death were urosepsis (OR=79.97), non-functioning transplant (OR=5.92), presence of lower respiratory tract infection (OR=7.48), blood system pathology (OR=10.27) and cardiovascular diseases (OR=2.52). Based on the risk factors, a prognostic model of the death risk was constructed. The developed model demonstrated high accuracy (AUC=0.96, 95% CI 0.93–0.99), with a sensitivity of 95 ,7% and specificity of 91.2%.
Conclusion. The identified predictors highlight the need for careful monitoring and early intervention in patients hospitalized for graft pyelonephritis, especially in the presence of urosepsis, non-functioning graft and concomitant infectious complications. The prognostic model provides risk stratification for patients, which may improve clinical outcomes.
About the Autors
Sergey S. Andreev – Head of the Department of Clinical Pharmacology, City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow,123182; e-mail: nerowolf@mail.ru. ORCID: https://orcid.org/0000-0002-9147-4636.
Ruslan N. Trushkin – Dr.Sci. (Med.), Head of the Urology Department, City Clinical Hospital No. 52 of Moscow Healthcare Department.
Address: 3 Pekhotnaya st.,Moscow, 123182; e-mail: uro52@mail.ru. http://orcid.org/0000-0002-3108-0539.
Teymur K. Isaev – Dr.Sci. (Med.), Urologist, Urology Department, City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: dr.isaev@mail.ru. ORCID: https://orcid.org/0000-0003-3462-8616.
Lyudmila Yu. Artyukhina – Cand.Sci.(Med.), Head of the 1st Nephrology Department (Transplanted Kidney Pathology Department), City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: arlyu-1404@yandex.ru. ORCID: https://orcid.org/0000-0003-3353-1636.
Nadiya F. Frolova – Cand.Sci.(Med.), Deputy Chief Physician for Nephrological Care, City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: nadiya.frolova@yandex.ru. ORCID: http://orcid.org/0000-0002-6086-5220.
Nadezhda N. Ilyukhina – Clinical Pharmacologist at the Department of Clinical Pharmacology, City Clinical Hospital No. 52 of Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182; e-mail gkb52@zdrav.mos.ru.
Polina O. Narusova – Clinical Pharmacologist at the Department of Clinical Pharmacology, City Clinical Hospital No. 52 of Moscow Healthcare Department.
Address: 3 Pekhotnaya st., Moscow, 123182; e-mail: gkb52@zdrav.mos.ru. ORCID: http://orcid.org/0000-0002-2960-5236.
Sherzod P. Abdullaev – Cand.Svi.(Biol.), Project Analyst, City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182;
e-mail: abdullaevsp@gmail.com. ORCID: http://orcid.org/0000-0001-9001-1499.
Aleksandr D. Dushkin – Cand.Sci.(Med.), Project Analyst, City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182;
e-mail: alex@drdushkin.ru. ORCID: https://orcid.org/0000-0002-8013-5276.
Maryana A. Lysenko – Dr.Sci. (Med.), Professor, Chief Physician of the City Clinical Hospital No. 52 of Moscow Healthcare Department. Address: 3 Pekhotnaya st., Moscow, 123182; Professor at the Department of General Therapy, Faculty of Continuous Professional Education, Pirogov Russian National Research Medical University
(Pirogov University). Address: 1 Ostrovityanov st., Moscow, 117997; e-mail: gkb52@zdrav.mos.ru. ORCID: https://orcid.org/0000-0001-6010-7975.
Marina V. Zhuravleva – Dr.Sci. (Med.), Professor, Chief External Expert in Clinical Pharmacology of the Moscow Health Department, Deputy Director of the Center for Clinical Pharmacology, Scientific Center for Expertise of Medical Products. Address: Bldg. 2, 8 Petrovsky blvd, Moscow,127051; Professor at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University). Address: Bldg. 2, 8 Trubetskaya st., Moscow, 119048; e-mail: clinpharm23@mail.ru. ORCID: https://orcid.org/0000-0002-9198-8661.
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