Clinical characteristics and pathogenetic mechanisms of development of cognitive disfucntion in chronic kidney disease patients


I.V. Rogova 1, V.V. Fomin 1, I.V. Damulin 1, E.G. Minakova 2, O.Yu Seklivanova 2, E.V. Shashkova 3, Yu.A. Petleva 4

1 State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation
Aim. Assessment of cognitive dysfunction risk factors and it’s association with vascular remodeling in patients with chronic kidney disease (CKD).
Methods. 51 patients with CKD (age 53±10 years): 20 – with CKD I-II stage, 20 – CKD III stage, 11 – CKD IV stage were included into the study. Glomerular filtration rate was calculated by MDRD formula. Neuropsychological tests were used for diagnosing of cognitive dysfunction. Magnetic resonance tomography (MRT) of brain, ultrasound scanning of carotid arteries and measurement of carotid-femoral pulse wave velocity were performed.
Results. In patients with CKD III – IV more often, than patients with CKD III – IV showed signs of cognitive dysfunction. CKD III – IV is independent risk factor for cognitive impairment (OR 27,32, 95%, CI 4,3 – 172,9, p<0,001). Cognitive dysfunction is connected with homocysteine, creatinine level, anemia, visceral obesity and age. In patients with CKD and cognitive dysfunction MRT shown focal lesions in 9 (30%) of patients, leucoareosis in 7 (2,3%), lateral ventricular widening in 15 (50%). Carotid intima-media thickness and carotid-femoral pulse wave velocity were also associated with frequency and severity of cognitive dysfunction.
Conclusion. Chronic kidney disease is a risk factor for cognitive dysfunction.

About the Autors


Rogova I.V. – Ph.D. Student at Therapy and Professional Diseases department at Preventive Medicine Faculty at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation
E-mail: rogovavit@gmail.com;
Fomin V.V. – professor at therapy and professional diseases department of Preventive medicine faculty, Dean of Medical Faculty at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation. Ph.D.;
Damulin I.V. – Diseases of Nervous Diseses department professor , vice - director on Nervous system division of Health-saving Technologies center at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation, Ph.D.
Minakova E.G. – head of department for ultrasound diagnostic Nephrology, Internal and Professional diseases Clinic n.a. E.M. Tareev University clinical hospital #3 at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation
Shashkova E.V. – Ph.D., head of radial diagnostic department of Neurologycal disease clinic n.a. A.Ya.KozhevnikovUniversity clinical hospital #3 at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation
Selivanova O.Yu. – head of functional diagnostic room of Nephrology, Internal and Professional diseases Clinic n.a. E.M. Tareev University clinical hospital #3 at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation


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