Urinary level of podocyte damage and self-defence markers in patients with chronic glomerulonephritis


N.V. Tchebotareva, N.V. Neprintseva, O.A. Es’kova, I.N. Bobkova, L.V. Kozlovskaya

State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation
Aim. Assessment of severity of podocyte damage in patients with chronic glomerulonephitis (CGN) according
to proteinuria level and urinary excretion of interleuki-6 (IL-6) and heat shock protein-27 (HSP-27).
Methods. 73 patients with CGN were included into the study; 30 of the – with nephrotic syndrome. Podocyturia was assessed by floucytometry with podocalixin-marked antibodies, urinary levels of IL-6 and HSP-27 were detetmined by ELISA.
Results. Pateints with active CGN demonstrate high levels of podocyturia, correlating with proteinuria, seveirity of nephrotic syndrome and urinary excretion of IL-6. Podocituria detects unfavorable renal prognosis.
Conclusion. Podocituria can be used as a marker of disease severity and prognosis in patients with chronic glomerulonephritis.

About the Autors


N.V. Tchebotareva – leading research associate at department of nephrology and hemodialysis of Scientific Research Institute of Uronephrology and human reproductive health of State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation, Ph.D.
N.V. Neprintseva – Ph.D. student at department of nephrology and hemodialysis at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation
O.A. Es’kova – Ph.D. student at department of nephrology and hemodialysis at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation
I.N. Bobkova – head of department of nephrology of Scientific Research Institute of Uronephrology and human reproductive health of State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health of Russian Federation, Ph.D.
E-mail: irbo.mma@mail.ru;
L.V. Kozlovskaya – professor at therapy and professional diseases department of Preventive medicine faculty at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation. Ph.D.


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